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Table 1 Description of included studies investigating the association between TAI status and IVF/ICSI outcomes

From: Thyroid autoimmunity and IVF/ICSI outcomes in euthyroid women: a systematic review and meta-analysis

Study Year Study Population Study Design Thyroid autoantibodies tested and cut-off values Assay used for thyroid antibodies TAI+ patients TAI+ TSH Levels TAI- patients TAI- TSH Values ART procedure Outcomes Quality of evidence a
Muller [12] 1999 Women undergoing IVF March 1994–March 1996 Prospective TPO-Ab: normal range < = 80 IU/ml RIA 25 3.5+/−3.6 148 1.7+/−1.7 IVF MR 7
Poppe [13] 2003 Women undergoing ART October 1999–November 2000 Prospective TPO-Ab: normal range < 100 KU/L RIA 32 1.6 (0.02–4.1) 202 1.3 (0.05–3.6) IVF/ICSI CPR, CMR, BPL, MR, LBR/CP, ET 8
Negro [30] 2007 Women undergoing ART Jan 2000- Jan 2006 Retrospective Cohort TPO-Ab: normal range < 100 KU/I RIA 374 - 42 - IVF/ICSI MR, ET, NOR 7
Kilic [31] 2008 Women with unexplained fertility undergoing first ART procedure Jan 2006-Feb 2007 Prospective Cohort TPOAb: normal< 34 IU/ml,
Tg Ab: normal < 150 IU/ml
Electrochemiluminescence 23 2.21+/−1.25 31 1.99+/− 1.11 IVF CPR, BPL, NOR 7
Revelli [32] 2009 Women undergoing ART Feb 2004 – May 2008 Retrospective Cohort TPO-Ab: normal range < 35 U/ml
TG-Ab: normal range < 40 IU/ml
Immunofluorescence 38
(52 cycles)
2+/− 1.2 200 2.2+/− 1.1 IVF CPR, CMR, MR, NOR 8
Zhong [33] 2012 Women undergoing ART Aug 2009 - Aug 2010 Retrospective Cohort TPO-Ab: normal range < 5.61 IU/ml
TG-Ab: normal range < 4.11 IU/ml
CMIA 90
(156 cycles)
676
(981 cycles)
IVF/ICSI MR, IR, ET, NOR 8
Karacan [34] 2013 Infertile women undergoing ICSI May 2009–July 2012 Prospective cohort TPO-ab: normal < 35 IU/ml Tg-Ab: normal< 115 IU/ml ECLIA 34 1.89+/− 1.18 219 1.74+/− 1.24 ICSI CPR, CMR, BPL, MR, IR, ET, NOR 8
Chai [14] 2014 Infertile women undergoing first IVF/ICSI cycle between Feb 2007 and Dec 2009* Retrospective cohort TPO-ab: normal < 9 IU/ml Tg-Ab: normal< 4 IU/ml TPO antibody reagent pack 89 1.5 (0.35–2.47) 419 1.4 (0.32–2.50)   CPR, CMR, MR, LBR/CP 7
Tan [35] 2014 Women undergoing ICSI 1997–2006 Retrospective TPO-ab: normal < 35 U/L
Tg-Ab: normal < 40 U/L
Chemiluminescence 110 1.7+/−  0.7 725 1.5+/−  0.6 ICSI CPR, CMR, MR, LBR/CP 8
Lukaszuk [15] 2015 Women undergoing ART April 2010–April 2012 Retrospective TPO-ab: normal < 34 IU/mL ECLIA 114 All euthyroid 495 All euthyroid ICSI CPR, CMR, MR, LBR/CP, IR 7
Sakar [23] 2016 Women undergoing ICSI July 2013–March 2014 Prospective case-control TPO-ab: normal < 35 U/L
Tg-Ab: normal < 78 U/L
ELISA 31
(32 cycles)
2.35+/− 1.84 121
(126 cycles)
1.97+/− 2.07 ICSI CPR, CMR, BPL, MR, NOR 8
Chen [21] 2017 Infertile women Jan 2015-Dec 2015** prospective cohort TPO-Ab: normal range < 34kIU/L ECLIA 214 - 844 - IVF/ ICSI CPR, CMR, IR, ET, NOR 8
Zhuang [24] 2017 Women undergoing ICSI Mar 2011-Oct 2013*** Retrospective cohort TPO-Ab, TG-Ab
Cut-off values not reported
Not Reported 127 All euthyroid 662 All euthyroid IVF CPR, NOR 7
Devi [22] 2019 Women undergoing IVF Nov 2014- Apr 2016 Prospective cohort TPO-ab: normal < 50 IU/ml
Tg-Ab: normal < 100 IU/ml
ELISA 17 All euthyroid 64 All euthyroid IVF CPR, NOR 8
  1. aAssessed using the Newcastle Ottawa Scale
  2. *Only euthyroid women included
  3. **Only women with TPO-ab were included to prevent sample overlap
  4. ***Only women with TSH ≤ 2.5mIU/L included
  5. CPR, clinical pregnancy rate; CMR, clinical miscarriage rate; BPL, biochemical pregnancy loss; MR; miscarriage rate according to all definitions; LBR/CP, live birth rate per clinical pregnancy; LBR/ cycle, live birth rate per cycle; IR, implantation rate; ET, numbers of embryos transferred; NOR, number of oocytes retrieved