Skip to main content
Fig. 4 | Reproductive Biology and Endocrinology

Fig. 4

From: Developmental programming: gestational testosterone excess disrupts LH secretion in the female sheep fetus

Fig. 4

Effects of gestational T excess and pharmacological intervention with an androgen antagonist (flutamide) or an insulin sensitizer (rosiglitazone) on the protein expression of LHβ and key regulators of LH synthesis/secretion in the pituitary from female fetuses. Representative Western blots and mean (± SEM) protein level ratio of LHβ/GAPDH (panel a), GnRH-R/GAPDH (panel b), AR/GAPDH (panel c), and ERα/GAPDH (panel d) in the anterior pituitary from females fetuses treated with prenatal vehicle (C, n = 10), prenatal T (T, n = 6), prenatal T and prenatal flutamide (TF, n = 6), and prenatal T and prenatal rosiglitazone (TR, n = 6). Means with different superscripts are significantly (P < 0.05) different

Back to article page

Reproductive Biology and Endocrinology

ISSN: 1477-7827

Contact us