Skip to main content

Table 2 Overall and ethnic subgroup summary effects of the LD1 PON variants with PCOS

From: Paraoxonase single nucleotide variants show associations with polycystic ovary syndrome: a meta-analysis

Comparison
Genetic model number of cases/controls (pre-outlier)
n Test of association Test of heterogeneity n Test of association Test of heterogeneity
OR 95% CI Pa PHET I2 (%) Analysis model OR 95% CI Pa PHET I2 (%) Analysis model
Pre-outlier Post-outlier
Overall
 2114/1588
  var 11 1.44 1.24–1.67 0.00001*†‡ 0.17 29 Fixed
  wt 11 0.81 0.57–1.17 0.26 0.00001 85 Random 10 0.90 0.84–1.10 0.59 0.16 31 Fixed
  het 11 1.00 0.78–1.28 0.97 0.0001 74 Random 10 0.85 0.76–0.96 0.008 0.60 0 Fixed
Asian
 1547/1270
  var 6 1.41 1.20–1.65 0.0001*†‡ 0.99 0 Fixed
  wt 6 0.94 0.74–1.20 0.62 0.03 60 Random 5 0.83 0.80–0.98 0.03 0.48 0 Fixed
  het 6 0.84 0.74–0.96 0.008 0.42 0 Fixed
Caucasian
 567/318
  var 5 1.39 0.55–3.51 0.49 0.005 73 Random 4 1.01 0.63–1.61 0.97 0.36 6 Fixed
  wt 5 0.67 0.24–1.84 0.44 0.0001 91 Random 4 1.09 0.77–1.53 0.63 1.00 0 Fixed
  het 5 1.30 0.60–2.75 0.49 0.001 84 Random 4 0.91 0.65–1.29 0.61 0.52 0 Fixed
  1. LD linkage disequilibrium, LD1 (rs854560 + rs662), PON Paraoxonase, PCOS polycystic ovary syndrome, var variant, wt wild-type, het heterozygous genotype (var + wt), n number of studies, OR odds ratio, CI confidence interval, Pa P-value for association, PHET P-value for heterogeneity, I2 measure of variability; values in bold indicate significant associations; *survived the Bonferroni correction; † without evidence of publication bias; ‡ robust