Paraoxonase single nucleotide variants show associations with polycystic ovary syndrome: a meta-analysis

Table 2 Overall and ethnic subgroup summary effects of the LD1 PON variants with PCOS

Comparison Genetic model number of cases/controls (pre-outlier)	n	Test of association			Test of heterogeneity			n	Test of association			Test of heterogeneity
	n	OR	95% CI	P^a	P_HET	I² (%)	Analysis model	n	OR	95% CI	P^a	P_HET	I² (%)	Analysis model
	Pre-outlier							Post-outlier
Overall
2114/1588
var	11	1.44	1.24–1.67	0.00001*†‡	0.17	29	Fixed	–	–	–	–	–	–	–
wt	11	0.81	0.57–1.17	0.26	0.00001	85	Random	10	0.90	0.84–1.10	0.59	0.16	31	Fixed
het	11	1.00	0.78–1.28	0.97	0.0001	74	Random	10	0.85	0.76–0.96	0.008†	0.60	0	Fixed
Asian
1547/1270
var	6	1.41	1.20–1.65	0.0001*†‡	0.99	0	Fixed	–	–	–	–	–	–	–
wt	6	0.94	0.74–1.20	0.62	0.03	60	Random	5	0.83	0.80–0.98	0.03	0.48	0	Fixed
het	6	0.84	0.74–0.96	0.008	0.42	0	Fixed	–	–	–	–	–	–	–
Caucasian
567/318
var	5	1.39	0.55–3.51	0.49	0.005	73	Random	4	1.01	0.63–1.61	0.97	0.36	6	Fixed
wt	5	0.67	0.24–1.84	0.44	0.0001	91	Random	4	1.09	0.77–1.53	0.63	1.00	0	Fixed
het	5	1.30	0.60–2.75	0.49	0.001	84	Random	4	0.91	0.65–1.29	0.61	0.52	0	Fixed

LD linkage disequilibrium, LD1 (rs854560 + rs662), PON Paraoxonase, PCOS polycystic ovary syndrome, var variant, wt wild-type, het heterozygous genotype (var + wt), n number of studies, OR odds ratio, CI confidence interval, P^a P-value for association, P_HET P-value for heterogeneity, I² measure of variability; values in bold indicate significant associations; *survived the Bonferroni correction; † without evidence of publication bias; ‡ robust

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