Paraoxonase single nucleotide variants show associations with polycystic ovary syndrome: a meta-analysis

Table 1 Characteristics of the included studies that examined associations of PON single nucleotide variants with PCOS

	Included in previous meta-analyses				First author	[R]	Year	Country	Ethnicity	Diagnostic criteria	PON1 variants	Clark-Baudouin score
	Liu [21]	Liao [20]	Gu [19]	Chen [18]	First author	[R]	Year	Country	Ethnicity	Diagnostic criteria	PON1 variants	Clark-Baudouin score
1	yes	yes	no	yes	San Millan	[40]	2004	Spain	Caucasian	National Institute of Health	rs85460, rs662, rs705379	8
2	no	yes	no	no	Mohammed	[41]	2009	Egypt	African	National Institute of Health	rs854560^a, rs705379	5
3	yes	yes	yes	yes	Lenarcik	[42]	2010	Poland	Caucasian	Rotterdam	rs854560	6
4	yes	yes	no	no	Zhang (Ch)	[43]	2011	China	Asian	Rotterdam	rs705379	6
5	yes	yes	yes	yes	Wang	[38]	2012	China	Asian	Rotterdam	rs854560, rs662	7
6	yes	yes	yes	yes	Paltoglu	[44]	2013	Greece	Caucasian	National Institute of Health	rs662, rs705379	8
7	yes	yes	yes	yes	Ferk	[45]	2014	Slovenia	Caucasian	Rotterdam	rs705379	6
8	yes	yes	yes	yes	Dadachanji	[46]	2015	India	Asian	Rotterdam	rs854560, rs662	8
9	yes	yes	yes	yes	Zhang	[39]	2015	China	Asian	Rotterdam	rs854560, rs662, rs705379	7
10	no	no	no	no	Dadachanji	[47]	2018	India	Asian	Rotterdam	rs705379, rs854571, rs854572, rs854573, rs705381	8
11	no	no	no	no	Liu	[48]	2019	China	Asian	Rotterdam	rs7493 (PON2)	9
12	no	no	no	no	Nalkiran	[49]	2019	Turkey	Caucasian	Rotterdam	rs854560, rs662^a	8

PON Paraoxonase, PCOS polycystic ovary syndrome, (Ch) Chinese language, [R] reference number
^acontrol frequencies deviated from the Hardy-Weinberg Equilibrium

ISSN: 1477-7827