Fig. 2

PON LD1 overall association with PCOS in the var model. The diamond indicates a pooled increased risk effect (OR 1.44), significant (P^a = 0.00001) with low-level heterogeneity (P_HET = 0.17, I² = 29%). Squares indicate the OR in each study, with square sizes directly proportional to the weight contribution (%) of the study. Horizontal lines on either side of the squares represent 95% CIs. PON: paraoxonase; LD1: linkage disequilibrium 1; PCOS: polycystic ovary syndrome; var: variant; identifier after author name indicate 0 (rs854560) or 2 (rs662); OR: odds ratio; P^a: P-value for association; P_HET: P-value for heterogeneity; I²: measure of variability; CIs: confidence intervals