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Fig. 5 | Reproductive Biology and Endocrinology

Fig. 5

From: HLA-A and HLA-DRB1 may play a unique role in ovarian teratoma-associated anti-N-methyl-D-aspartate receptor encephalitis

Fig. 5

Immunohistochemical findings in the teratoma tissues of the NMDAR-E group and the control group. a HLA-A (+) cells were more densely aggregated in the teratoma tissues in the NMDAR-E (+) patients in comparison with those in the controls. b HLA-DRB1 (+) cells were evident in the teratoma tissues in the NMDAR-E (+) patients but were scarcely detected in the controls. c The IHC score values of HLA-A and HLA-DRB1 were significantly higher in the teratoma tissues of NMDAR-E (+) patients compared with those in tissues of controls. There were eight teratoma patients without NMDAR-E in the control group (C-01 to 08) and 4 teratoma patients with NMDAR-E in the NMDAR-E group (S-01 to 04). Data are represented as the mean ± SD. *P < .05, ** P < .01. bar = 100 μm. (: blood vessels, ▲: lymphatic vessels, ✚: germinal center, ↓: hair follicle, ←: sebaceous glands, red square: neuron, black square: glial cells)

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