From: Long non-coding RNAs (lncRNAs) in spermatogenesis and male infertility
lncRNA gene ID | Global targets | Functions | Disease specific targets | Reference |
---|---|---|---|---|
LINC00635 | CENPBa, FAM98B, GOLGA6L1, GOLGA6L22, GOLGA6L6, MLYCD, MUC2, RP11-573D15.8, RPGR, SNX8 | Cenpb−/− male mice were fertile but have low sperm content and testis weight. FAM98A, FAM98B along with DDX1 and C14orf166 are required for PRMT1 expression (which is important for spermatogenesis). The whole GOLGA6 family is highly expressed in testis. Overexpression of Rpgr in transgenic mice has led to increased flagellar defects and reduced sperm count. | – | |
LINC00174 | RP11-573D15.8, CTD-2095E4.4, GOLGA6L22, GOLGA6L6, RPGR, SNX8 | – | TAZ-involved in cancer progression. | – |
LINC00654 | ABI2, FAM98B, GOLGA6L22, GOLGA6L6, RP11-573D15.8, RP3-323A16.1, RPGR, SNX8 | – | – | – |
LINC00710 | ABI2, CCDC85C, FAM98B, RP11-573D15.8, RPGR, SNX8 | – | – | – |
LINC00226 | CCDC85C, FAM98B, SNX8, TPM2, C00717C00720L.1 | TPM2 was found to be up-regulated in cauda region as compared to caput/corpus region of human epididymis. | – | [118] |
LINC00326 | C9orf152, FLJ35934, GNB5, LINC00940, | GNB5 could play a role in acrosome biogenesis and vesicle trafficking. | – | [119] |
LINC00494 | ABI2, EMC10, FAM98B, GOLGA6L22, GOLGA6L6, IGFN1, RP11-573D15.8, RPGR, SNX8 | – | – | – |
LINC00535 | ABI2, FAM98B, SNX8 | – | – | – |
LINC00616 | ABI2, CCDC85C, EMC10, FAM98B, MLYCD, PARVG, RP11-573D15.8, RP3-323A16.1, RPGR, SNX8 | – | – | – |
LINC00662 | RP11-573D15.8 | – | LIN28A- involved in cell metastasis and stemness in lung cancer. | – |
LINC00668 | ABI2, EMC10, KCNQ1OT1, MIR6820, RP11-573D15.8, RP3-323A16.1, RPGR, SNX8 | KCNQ1OT1 is paternally expressed and plays a role in silencing of six genes Ascl2, Kcnq1, Cdkn1c, Slc22a18, Phlda2, and Osbpl5. | CDKN2B, CDKN2A, CDKN1A, CDKN1B, CDKN1C, EZH2, SUZ12, VEGFA- involved in cancer progression and cell proliferation. | [120] |
LINC00467 | RP3-323A16.1, RPGR | – | – | – |
LINC00608 | ABI2, EMC10, FAM98B, RP11-573D15.8, RP3-323A16.1, RPGR, SNX8 | – | – | – |
LINC00658 | ABI2, AP006621.9, B3GALNT2, CCDC85C, FAM98B, RP11-573D15.8, RPGR, SNX8 | – | – | – |