Fig. 3
From: Long non-coding RNAs (lncRNAs) in spermatogenesis and male infertility
Gene expression is regulated by lncRNAs in three ways. Transcriptional: lncRNA interacts with methylation and de-acetylation complex to affect gene expression. Post-transcriptional: lncRNA interacts with miRNA to inhibit its action (a), lncRNA is degraded by miRNA (b), competitive binding of lncRNA and miRNA to the target site on mRNA (c). Affecting alternative splicing: lncRNA facilitates alternative splicing by binding to the target site on pre-mRNA. Translational regulation: lnc recruits translational repressor to block translation (a), lnc recruits polysomes to promote translation (b)