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Table 4 Comparison of outcomes at LPS stage of different trigger medicine at FPS stage of DuoStim protocol

From: The best execution of the DuoStim strategy (double stimulation in the follicular and luteal phase of the same ovarian cycle) in patients who are poor ovarian responders

Characteristic uHCG 10,000 IU
n = 178
rHCG 250 μg
n = 101
GnRH-a 0.2 mg
n = 25
P value
AFC 5.10 ± 4.00 5.33 ± 4.83 4.29 ± 2.51 0.552
FSH (IU/L) 10.33 ± 5.47 9.99 ± 4.78 10.81 ± 4.77 0.759
Matemal age (years) 38.41 ± 5.08 37.98 ± 4.96 38.08 ± 5.64 0.784
Total dose of Gn (IU) 1619.52 ± 813.79 1695.50 ± 820.23 2027.40 ± 1410.64 0.093
Duration of stimulation (days) 6.97 ± 2.89 7.21 ± 2.95 8.32 ± 4.84 0.127
follicle of >10 mm on HCG day 4.65 ± 4.08 4.78 ± 5.40 4.28 ± 3.29 0.884
No. of oocyte retrieved 3.61 ± 3.85 3.64 ± 5.88 3.08 ± 2.41 0.848
No. of fertilized oocytes 2.31 ± 2.26 2.19 ± 3.88 2.12 ± 1.62 0.923
No. of cleaved embryos 2.25 ± 2.21 2.14 ± 3.81 2.08 ± 1.58 0.931
No. of cryopreserved embryos 1.78 ± 1.89 1.90 ± 3.57 1.76 ± 1.30 0.918
No. of good quality embryos 1.56 ± 1.79 1.72 ± 3.36 1.64 ± 1.29 0.865
Fertilization rates (%) 63.45% 59.51% 68.83% 0.227
Cleaved embryos rates (%) 98.04% 98.63% 98.11% 0.864
Rate of cryopreserved embryos (%) 79.00% 88.89%* 84.62%* 0.008
Rate of good quality embryos (%) 69.50% 80.56%* 78.85%* 0.008
Pregnancy rate per oocyte retrieval (%) 26.23%(32/122) 20.00%(14/70) 28.57%(6/21) 0.562
Pregnancy rate per FET (%) 46.38%(32/69) 48.28%(14/29) 50.00%(6/12) 0.966
Implantation rate (%) 27.84%(49/176) 33.90% (20/59) 33.33% (10/30) 0.614
Spontaneous abortion rate (%) 21.88%(7/32) 14.29%(2/14) 33.33%(2/6) 0.625
  1. Data are presented as number (%) unless otherwise indicated. Independent t-test was used to compare continuous variables, and Chi-squared test or Fisher’s exact test for categorical ones
  2. *Compared with uHCG 10,000 IU Group, P < 0.05