Table 4 Comparison of outcomes at LPS stage of different trigger medicine at FPS stage of DuoStim protocol
Characteristic | uHCG 10,000 IU n = 178 | rHCG 250 μg n = 101 | GnRH-a 0.2 mg n = 25 | P value |
|---|---|---|---|---|
AFC | 5.10 ± 4.00 | 5.33 ± 4.83 | 4.29 ± 2.51 | 0.552 |
FSH (IU/L) | 10.33 ± 5.47 | 9.99 ± 4.78 | 10.81 ± 4.77 | 0.759 |
Matemal age (years) | 38.41 ± 5.08 | 37.98 ± 4.96 | 38.08 ± 5.64 | 0.784 |
Total dose of Gn (IU) | 1619.52 ± 813.79 | 1695.50 ± 820.23 | 2027.40 ± 1410.64 | 0.093 |
Duration of stimulation (days) | 6.97 ± 2.89 | 7.21 ± 2.95 | 8.32 ± 4.84 | 0.127 |
follicle of >10 mm on HCG day | 4.65 ± 4.08 | 4.78 ± 5.40 | 4.28 ± 3.29 | 0.884 |
No. of oocyte retrieved | 3.61 ± 3.85 | 3.64 ± 5.88 | 3.08 ± 2.41 | 0.848 |
No. of fertilized oocytes | 2.31 ± 2.26 | 2.19 ± 3.88 | 2.12 ± 1.62 | 0.923 |
No. of cleaved embryos | 2.25 ± 2.21 | 2.14 ± 3.81 | 2.08 ± 1.58 | 0.931 |
No. of cryopreserved embryos | 1.78 ± 1.89 | 1.90 ± 3.57 | 1.76 ± 1.30 | 0.918 |
No. of good quality embryos | 1.56 ± 1.79 | 1.72 ± 3.36 | 1.64 ± 1.29 | 0.865 |
Fertilization rates (%) | 63.45% | 59.51% | 68.83% | 0.227 |
Cleaved embryos rates (%) | 98.04% | 98.63% | 98.11% | 0.864 |
Rate of cryopreserved embryos (%) | 79.00% | 88.89%* | 84.62%* | 0.008 |
Rate of good quality embryos (%) | 69.50% | 80.56%* | 78.85%* | 0.008 |
Pregnancy rate per oocyte retrieval (%) | 26.23%(32/122) | 20.00%(14/70) | 28.57%(6/21) | 0.562 |
Pregnancy rate per FET (%) | 46.38%(32/69) | 48.28%(14/29) | 50.00%(6/12) | 0.966 |
Implantation rate (%) | 27.84%(49/176) | 33.90% (20/59) | 33.33% (10/30) | 0.614 |
Spontaneous abortion rate (%) | 21.88%(7/32) | 14.29%(2/14) | 33.33%(2/6) | 0.625 |