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Table 2 Comparison of the FPS and LPS stage within DuoStim protocol

From: The best execution of the DuoStim strategy (double stimulation in the follicular and luteal phase of the same ovarian cycle) in patients who are poor ovarian responders

Characteristic FPS stage
n = 304
LPS stage
n = 304
P value
Total dose of Gonadotrophin (IU) 1359.51 ± 1135.84 1678.25 ± 882.64* 0.000
Duration of stimulation (days) 6.10 ± 3.48 7.16 ± 3.12* 0.000
E2 on HCG day (pg/ml) 669.27 ± 527.86 1377.95 ± 1155.53* 0.000
P4 on HCG day (ng/ml) 0.63 ± 0.95 14.98 ± 14.35* 0.000
LH on HCG day (IU/L) 5.75 ± 5.50 3.94 ± 4.80* 0.000
Follicles≥14 mm on HCG day 1.46 ± 0.85 3.27 ± 2.94* 0.000
Follicles 10-13 mm on HCG day 0.61 ± 1.01 1.39 ± 2.06* 0.000
Follicles≤10 mm on HCG day 2.07 ± 1.47 4.66 ± 4.49* 0.000
No. of oocyte retrieved 1.71 ± 1.30 3.58 ± 4.54* 0.000
No. of normal fertilized oocyte 1.09 ± 0.91 2.25 ± 2.85* 0.000
No. of cleaved embryos 1.05 ± 0.91 2.20 ± 2.80* 0.000
No. of cryopreserved embryos 0.90 ± 0.78 1.82 ± 2.54* 0.000
No. of good quality embryos 0.79 ± 0.76 1.62 ± 2.40* 0.000
Fertilization rate (%) 62.43% 62.50% 0.978
Cleaved embryos rate (%) 98.77% 98.24% 0.531
Rate of cryopreserved embryos (%) 85.93% 82.63% 0.188
Rate of good quality embryos (%) 74.69% 73.80% 0.766
Formed blastulation rate (%) 48.48% 67.42%* 0.037
Lesser quality embryos formed blastulation rate (%) 23.08%(3/13) 32.08%(17/53) 0.527
Pregnancy rate per FET (%) 26.42%(14/53) 47.27%(52/110)* 0.011
Pregnancy rate per oocyte retrieval (%) 7.37%(14/190) 24.41%(52/213)* 0
Implantation rate (%) 14.48% (21/145) 29.81% (79/265)* 0.001
Spontaneous abortion rate (%) 42.85%(6/14) 21.15%(11/52) 0.099
  1. Data are presented as number (%) unless otherwise indicated. Independent t-test was used to compare continuous variables, and Chi-squared test or Fisher’s exact test for categorical ones
  2. *Compared with FPS Group, P < 0.05