Fig. 2

circRNA can be generated either with the help of reverse complementary and exported from the nucleus a: Argonaute proteins loaded with miRNAs as sponge b: In the cytoplasm,the circRNA might be bound with RNA-binding proteins c: translating into peptide in the ribosomes d: or direct degradation e: causing degradation of the circRNA with the help of endonucleases f: the enclosure of circRNAs in vesicle that would be released into the extracellular space would remove circRNAs with the help of endonucleases from the cytoplasm g: the circRNAs may reach other cells or tissues and therefore act as messenger molecules or direct degradation