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Table 3 Main results for the MTHFR 1298A/C polymorphism in the meta-analysis

From: Association of the MTHFR 677C>T and 1298A>C polymorphisms and male infertility risk: a meta-analysis

Variables

Cases/Controls

CC vs. AA

CA vs. AA

CC + CA vs. AA

CC vs. CA + AA

OR(95% CI)

P *

OR (95% CI)

P *

OR (95% CI)

P *

OR (95% CI)

P *

Total

5893/6303

1.23 (0.97, 1.55)

0.002

1.08 (0.96, 1.20)

p = 0.031

1.10 (0.99, 1.24)

0.014

0.86 (0.68, 1.08)

0.000

Ethnicity

Cases/Controls

TT vs. CC

TC vs. CC

TT + TC vs. CC

TT vs. TC + CC

OR(95% CI)

P *

OR (95% CI)

P *

OR (95% CI)

P *

OR (95% CI)

P *

Asian

4918/4782

1.23 (0.92, 1.64)

0.010

1.11 (0.99, 1.25)

0.227

1.13 (0.99, 1.30)

0.050

0.87 (0.67, 1.13)

0.006

Caucasian

1065/1521

1.21 (0.96, 1.53)

0.258

0.88 (0.74, 1.05)

0.370

0.91 (0.78, 1.07)

0.671

0.82 (0.52, 1.30)

0.096

  1. *P value of the chi- square test for heterogeneity