Table 2 Main results for the MTHFR 677C > T polymorphism in the meta-analysis
From: Association of the MTHFR 677C>T and 1298A>C polymorphisms and male infertility risk: a meta-analysis
Variables | Cases/Controls | TT vs. CC | TC vs. CC | TT + TC vs. CC | TT vs. TC + CC | ||||
OR(95% CI) | P * | OR (95% CI) | P * | OR (95% CI) | P * | OR (95% CI) | P * | ||
Total | 9662/9154 | 1.62 (1.36, 1.93) | 0.00 | 1.28 (1.14, 1.44) | 0.00 | 1.37 (1.21, 1.55) | 0.00 | 0.70 (0.61, 0.81) | 0.00 |
Ethnicity | Cases/Controls | TT vs. CC | TC vs. CC | TT + TC vs. CC | TT vs. TC + CC | ||||
OR(95% CI) | P * | OR (95% CI) | P * | OR (95% CI) | P * | OR (95% CI) | P * | ||
Asian | 7989/6887 | 1.78 (1.48–2.16) | 0.01 | 1.35 (1.20–1.53) | 0.00 | 1.46 (1.29–1.65) | 0.00 | 0.66 (0.56–0.77) | 0.08 |
Caucasian | 1673/2267 | 2.23 (0.84–1.80) | 0.00 | 1.02 (0.83–1.27) | 0.03 | 1.08 (0.86–1.36) | 0.00 | 0.87 (0.63–1.20) | 0.00 |