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Table 2 Controlled ovarian stimulation, IVF outcomes and OS markers in FF

From: Growth hormone alleviates oxidative stress and improves the IVF outcomes of poor ovarian responders: a randomized controlled trial

  POR-GH (n = 52) POR-C (n = 53) Non-POR (n = 58)
rFSH doses (IU) a,b 2491.46 ± 996.47 2499.87 ± 1345.16 1875.09 ± 467.39
rFSH duration (d) a,b 8.93 ± 2.57 8.97 ± 4.11 10.65 ± 1.65
E2 on trigger day (pg/mL) a,b 985.13 ± 348.44 887.85 ± 372.21 1956.10 ± 558.48
Endometrial thickness (mm) b,c 9.65 ± 1.84 8.61 ± 1.23 10.33 ± 1.93
Oocytes retrieved a,b 3.71 ± 2.50 3.24 ± 2.56 12.51 ± 6.81
MII oocytes a,b 3.18 ± 1.78 2.87 ± 1.89 9.95 ± 4.28
Fertilized oocytes (2PN) a,b 2.36 ± 1.86 2.02 ± 1.21 7.04 ± 4.29
Cleaved embryos a,b,c 2.31 ± 1.81 1.73 ± 1.03 5.38 ± 3.62
Higher-quality embryos a,b,c 1.26 ± 0.65 0.72 ± 0.56 3.34 ± 2.78
Oocyte maturation rate (%) 82.38% (159/193) 83.02% (132/159) 79.48% (577/726)
Oocyte fertilization rate 74.21% (118/159) 70.45% (93/132) 70.71% (408/577)
Embryo formation rate a,c 95.76% (113/118) 83.87% (78/93) 76.47% (312/408)
Higher-quality embryo formation rate b,c 52.54% (62/118) 35.48% (33/93) 47.55% (194/408)
No. ET 1.58 ± 0.51 1.59 ± 0.48 1.43 ± 0.50
Excluded cycle rate (%) b 5.77% (3/52) 15.09% (8/53) 0/58
Implantation rate (%) b,c 28.21% (22/78) 9.72% (7/72) 43.37% (36/83)
Clinical pregnancy rate (%) b,c 38.77% (19/49) 13.33% (6/45) 53.44% (31/58)
Miscarriage rate (%) 21.05% (4/19) 33.33% (2/6) 6.45% (2/31)
Multiple pregnancy rate (%) 15.78% (3/19) 16.67% (1/6) 16.13% (5/31)
In FF
 MDA (nmol/mL) a,b 2.27 ± 0.69 3.02 ± 1.10 1.33 ± 0.67
 SOD (U/mgprot) a,b 12.99 ± 2.32 11.21 ± 1.71 14.76 ± 1.93
 TAC (mmol Trolox Equiv./L) a,b,c 0.59 ± 0.13 0.42 ± 0.16 0.71 ± 0.11
 TOS (μmol H2O2 Equiv./L) a,b,c 8.06 ± 1.19 10.14 ± 4.86 5.67 ± 1.09
 OSI a,b,c 16.49 ± 8.19 23.87 ± 10.13 8.16 ± 1.86
  1. Note: Data are presented as the mean ± SD or percentage (number). 2PN Number of two pronuclear zygotes, ET embryos transferred, FF follicular fluid, MDA malondialdehyde, SOD superoxide dismutase TAC total antioxidant capacity, TOS total oxidant status, OSI oxidative stress index. A chi-squared test was performed to compare the rates of cycle cancellation, implantation, clinical pregnancy, miscarriage and multiple pregnancy
  2. a P < 0.05 the POR-GH group versus the non-POR group
  3. b P < 0.05 the POR-C group versus the non-POR group
  4. c P < 0.05 the POR-GH group versus the POR-C group