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Fig. 3 | Reproductive Biology and Endocrinology

Fig. 3

From: Intra-ovarian injection of platelet-rich plasma into ovarian tissue promoted rejuvenation in the rat model of premature ovarian insufficiency and restored ovulation rate via angiogenesis modulation

Fig. 3

Confirmation of POI modelling using H&E staining. Microscopic imaging revealed both primary and advanced follicle stages in sections prepared from healthy ovaries. VCD administration promoted pathological changes in the structure of follicles indicated by atresia and shrinkage. All follicles, including primary secondary and antral stages, exhibited abnormal structure, detachment, disintegration, and degeneration of epithelial cells and granulosa cells in primary, secondary and antral follicles compared to the follicles from the control samples (a). Arrows = morphological alterations within the oocyte; arrow heads = detaching granulosa cells. The quantitative analysis revealed the depletion of morphologically normal follicles after VCD administration (n = 3). The number of atretic follicles was also increased after the 15-day injection of VCD b)

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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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