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Fig. 1 | Reproductive Biology and Endocrinology

Fig. 1

From: Histone acetylation and the role of histone deacetylases in normal cyclic endometrium

Fig. 1

Chromatin remodelling. Fundamental structure of chromatin called nucleosome consists of two sets of four histone proteins H2A, H2B, H3 and H4. Protruding histone tails undergo post translational modifications such as methylation, acetylation, ubiquitination and phosphorylation. The numbers indicate the positions of targeted lysine groups. Histone acetylation alters the conformation of chromatin structure in nucleus by relaxing the chromatin and allowing transcriptional activation. It is regulated by two sets of enzymes HATs and HDACs which add or remove acetyl group respectively from both histone and non-histone proteins, hence regulating gene transcription. (Created with BioRender.com)

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