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Table 1 Characteristics of the studies included

From: The effect of growth hormone supplementation in poor ovarian responders undergoing IVF or ICSI: a meta-analysis of randomized controlled trials

Study Intervention GH Control Inclusion criteria Stimulation protocol
Safdarian L
(2019) [20]
GH 2.5 mg/day from day 8 or 0.1 mg/day from previous cycle day 3 f 70 35 any two of three criteria to be met: age ≥ 40 years; oocytes≤3; AFC < 5–7 or AMH < 0.5–1.1 ng/ml GnRH antagonist protocol
Norman RJ
(2019) [19]
GH 12 IU/day from day 1 of stimulation a 65 65 oocytes≤5; age ≤ 41; FSH ≤ 15 IU/l GnRH antagonist protocol
Lee YX
(2019) [18]
GH 4, 4, 2 IU for three successive days a 94 90 age ≥ 40; oocytes≤3; AFC < 5–7 or AMH < 0.5–1.1 ng/ml Long GnRH agonist protocol
Dakhly DMR
(2018) [17]
GH 2.5 mg from previous cycle day 21 b 120 120 any two of three criteria to be met: age ≥ 40 years; oocytes≤3; AFC < 5–7 or AMH < 0.5–1.1 ng/ml Long GnRH agonist protocol
Choe SA
(2018) [16]
GH 20 mg three times at mid-luteal, late luteal, and menstrual cycle day 2 c 62 65 age ≥ 40; oocytes≤3; AFC < 5–7 or AMH < 0.5–1.1 ng/ml GnRH antagonist protocol
Bassiouny YA
(2016) [14]
GH 2.5 mg from day 6 of stimulation b 68 73 any two of three criteria to be met: age ≥ 40 years; oocytes≤3; AFC < 5–7 or AMH < 0.5–1.1 ng/ml GnRH antagonist protocol
Bayoumi YA
(2015) [21]
GH 2.5 mg from day 6 of stimulation f 84 88 any two of three criteria to be met: age ≥ 40 years; oocytes≤3; AFC < 5–7 or AMH < 0.5–1.1 ng/ml microflare protoco
Eftekhar M
(2013) [22]
GH 4 IU/day from previous cycle day 21 c 40 42 failed IVF cycles≥1; oocytes≤3 GnRH antagonist protocol
Kucuk T
(2008) [23]
GH 12 IU/day from previous cycle day 21 b 31 30 responded poorly to high dose gonadotropin in first cycle GnRH agonist long protocol
Tesarik J
(2005) [24]
GH 8 IU/day from day 7 of stimulation a 50 50 age 41–44 years GnRH agonist long protocol
Suikkari A
(1996) [25]
GH 4 IU/day or 12 IU/day from menstrual cycle day 3 d 16 6 oocytes≤2 or ≥ 48 amples of hMG GnRH-a flare up protocol
Dor J
(1995) [26]
GH 18 IU on days 2, 4, 6 and 8 of the cycle e 7 7 17-β oestradiol on hCG day< 501 pg/ml; follicles≤4; oocytes≤3 GnRH agonist short protocol
Bergh C
(1994) [28]
GH 0.1 IU/kg during stimulation d 9 9 failed IVF attempts≥2, oocytes< 5, age 25–38 years GnRH agonist long protocol
Zhuang GL
(1994) [27]
GH 12 IU on alternate days a 12 15 previous sub-optimal response GnRH agonist long protocol
Owen EJ
(1991) [29]
GH 24 IU on alternate days during stimulation b 13 12 oocytes≤6, embryos≤3 microflare protoco
  1. a Participants administrated with GH (Saizen, Merck Serono)
  2. b Participants administrated with GH (Norditropin, Novo Nordisk)
  3. c Participants administrated with GH (Eutropin, LG)
  4. d Participants administrated with GH (Genotropin, Kabi pharmacia)
  5. e Participants administrated with GH (Bio-Gropin; Bio-Technology General)
  6. f The product name of GH was not mentioned