Baseline Parameters | Total (N = 88) | Normal Weight (N = 43) | Overweight (N = 45) | p-value between weights |
---|---|---|---|---|
Age (years) | 24.0 (20.0–28.0) | 24.0 (21.0–26.8) | 25.5 (17.3–29.8) | 0.697 |
BMI (kg/m2) | 23.2 (20.6–29.8) | 20.9 (19.2–21.9) | 30.6 (25.4–37.4) | < 0.001* |
Overweight | 51.1% (45/88) | 0% (0/43) | 100% (45/45) | – |
Waist (cm) | 84.0 (77.0–94.0) | 76.3 (73.6–81.5) | 93.8 (86.6–109.0) | < 0.001* |
Abdominally obese | 64.8% (57/88) | 32.6% (14/43) | 95.6% (43/45) | < 0.001* |
Fasting glucose (mg/dL) | 82.0 (78.0–86.8) | 80.5 (76.0–84.8) | 87.0 (81.3–91.0) | < 0.001* |
Fasting insulin (mIU/L) | 4.3 (2.0–12.9) | 2.0 (2.0–4.7) | 13.8 (6.5–21.4) | < 0.001* |
HOMA-IR | 0.8 (0.4–2.7) | 0.4 (0.4–1.0) | 2.9 (1.3–4.9) | < 0.001* |
75 g GTT 2 h (mg/dL) | 105.0 (85.8–129.0) | 91.5 (80.3–104.3) | 122.5 (115.3–142.3) | < 0.001* |
Glucose impaired | 14.8% (8/54) | 0.0% (0/28) | 30.7% (8/26) | 0.001* |
Testosterone (ng/ml) | 0.6 (0.4–0.8) | 0.5 (0.3–0.7) | 0.6 (0.4–0.9) | 0.676 |
SHBG (nmol/l) | 31.1 (19.0–45.0) | 42.2 (34.4–59.4) | 18.2 (15.2–25.3) | < 0.001* |
FAI (%) | 2.0 (1.2–3.4) | 1.1 (0.8–1.9) | 3.5 (2.2–4.4) | < 0.001* |
FSH (mIU/ml) | 6.1 (5.3–7.4) | 6.3 (5.5–7.8) | 5.6 (5.1–6.6) | 0.037* |
LH (mIU/ml) | 10.8 (7.7–14.9) | 13.8 (10.3–16.7) | 9.1 (6.4–10.8) | < 0.001* |
LH/FSH ratio | 1.7 (1.2–2.5) | 2.1 (1.8–2.7) | 1.5 (1.2–1.8) | 0.001* |
GOT (U/L) | 19.0 (17.0–23.0) | 18.5 (16.0–21.8) | 20.5 (19.0–31.3) | 0.464 |
GPT (U/L) | 17.0 (12.0–24.0) | 13.0 (11.0–17.8) | 24.0 (16.0–38.3) | < 0.001* |
hsCRP (mg/dL) | 0.09 (0.03–0.27) | 0.04 (0.02–0.08) | 0.31 (0.09–0.63) | < 0.001* |
8-OHdG | 34.6 (27.7–45.4) | 38.5 (30.6–53.9) | 31.0 (25.3–42.6) | 0.210 |
mtDNA-CN | 55.4 (26.1–100.3) | 47.2 (24.8–77.5) | 50.7 (23.9–98.6) | 0.786 |
Medication Parameters | ||||
Non-maximal regimen | 46.4% (39/84) | 64.3% (27/42) | 28.6% (12/42) | 0.001* |
Compliant | 61.9% (52/84) | 61.9% (26/42) | 61.9% (26/42) | 0.999 |