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Table 1 Characteristics of the patients in the cohort

From: Changes in peripheral mitochondrial DNA copy number in metformin-treated women with polycystic ovary syndrome: a longitudinal study

Baseline Parameters

Total

(N = 88)

Normal Weight

(N = 43)

Overweight

(N = 45)

p-value between weights

Age (years)

24.0 (20.0–28.0)

24.0 (21.0–26.8)

25.5 (17.3–29.8)

0.697

BMI (kg/m2)

23.2 (20.6–29.8)

20.9 (19.2–21.9)

30.6 (25.4–37.4)

< 0.001*

Overweight

51.1% (45/88)

0% (0/43)

100% (45/45)

Waist (cm)

84.0 (77.0–94.0)

76.3 (73.6–81.5)

93.8 (86.6–109.0)

< 0.001*

Abdominally obese

64.8% (57/88)

32.6% (14/43)

95.6% (43/45)

< 0.001*

Fasting glucose (mg/dL)

82.0 (78.0–86.8)

80.5 (76.0–84.8)

87.0 (81.3–91.0)

< 0.001*

Fasting insulin (mIU/L)

4.3 (2.0–12.9)

2.0 (2.0–4.7)

13.8 (6.5–21.4)

< 0.001*

HOMA-IR

0.8 (0.4–2.7)

0.4 (0.4–1.0)

2.9 (1.3–4.9)

< 0.001*

75 g GTT 2 h (mg/dL)

105.0 (85.8–129.0)

91.5 (80.3–104.3)

122.5 (115.3–142.3)

< 0.001*

Glucose impaired

14.8% (8/54)

0.0% (0/28)

30.7% (8/26)

0.001*

Testosterone (ng/ml)

0.6 (0.4–0.8)

0.5 (0.3–0.7)

0.6 (0.4–0.9)

0.676

SHBG (nmol/l)

31.1 (19.0–45.0)

42.2 (34.4–59.4)

18.2 (15.2–25.3)

< 0.001*

FAI (%)

2.0 (1.2–3.4)

1.1 (0.8–1.9)

3.5 (2.2–4.4)

< 0.001*

FSH (mIU/ml)

6.1 (5.3–7.4)

6.3 (5.5–7.8)

5.6 (5.1–6.6)

0.037*

LH (mIU/ml)

10.8 (7.7–14.9)

13.8 (10.3–16.7)

9.1 (6.4–10.8)

< 0.001*

LH/FSH ratio

1.7 (1.2–2.5)

2.1 (1.8–2.7)

1.5 (1.2–1.8)

0.001*

GOT (U/L)

19.0 (17.0–23.0)

18.5 (16.0–21.8)

20.5 (19.0–31.3)

0.464

GPT (U/L)

17.0 (12.0–24.0)

13.0 (11.0–17.8)

24.0 (16.0–38.3)

< 0.001*

hsCRP (mg/dL)

0.09 (0.03–0.27)

0.04 (0.02–0.08)

0.31 (0.09–0.63)

< 0.001*

8-OHdG

34.6 (27.7–45.4)

38.5 (30.6–53.9)

31.0 (25.3–42.6)

0.210

mtDNA-CN

55.4 (26.1–100.3)

47.2 (24.8–77.5)

50.7 (23.9–98.6)

0.786

Medication Parameters

Non-maximal regimen

46.4% (39/84)

64.3% (27/42)

28.6% (12/42)

0.001*

Compliant

61.9% (52/84)

61.9% (26/42)

61.9% (26/42)

0.999

  1. Data given as median (Q1-Q3); p-value < 0.05 is denoted with * for comparisons between normal-weight and overweight groups; BMI Body mass index, HOMA-IR Homeostatic model assessment-insulin resistance, GTT Glucose tolerance test, SHBG Sex hormone binding globulin, FAI Free androgen index, FSH Follicle stimulating hormone, LH Luteinizing hormone, GOT/GPT Glutamic oxaloacetic/pyruvic transaminase, hsCRP High sensitivity C-reactive protein, 8-OHdG 8-hydroxy-2-deoxyguanosine, mtDNA-CN Mitochondrial DNA copy number