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Table 1 Concentrations of NEFAs in different metabolic diseases in humans

From: Non-esterified fatty acids in the ovary: friends or foes?

Species Condition Biofluid Concentration of NEFA Ref.
Women Obese non-diabetic Plasma 290 μM [24]
Obese type 2 Diabetes Plasma 621 μM a
Human (sex not defined) Healthy Plasma 0.18 ± 0.09 (SD) g/L [25]
Type 2 Diabetes Plasma 0.45 ± 0.21 (SD) g/L
Women Normal weight Follicular Fluid 0.22 ± 0.02 (SD) mM [12]
Overweight Follicular Fluid 0.24 ± 0.03 (SD) mM
Obese Follicular Fluid 0.31 ± 0.08 (SD) mM a
Women 18.5 ≤ BMI ≤24.9 (n = 60) Serum 0.60 ± 0.20 (SD) mM [16]
25.0 ≤ BMI ≤29.9 (n = 26) Serum 0.70 ± 0.23 (SD) mM
BMI ≥30.0 (n = 20) Serum 0.70 ± 0.20 (SD) mM
Women Non Obese Follicular Fluid 0.16 ± 0.02 (SEM) meq/L [26]
  Obese Follicular Fluid 0.38 ± 0.04 (SEM) meq/L a  
Women Non Obese Plasma 0.49 ± 0.22 (SD) mM [13]
Obese Plasma 0.37 ± 0.18 (SD) mM
PCOS Non Obese Plasma 0.49 ± 0.23 (SD) mM
PCOS Obese Plasma 0.70 ± 0.13 (SD) mM a
Women Healthy Control Serum 4.36 ± 2.52 (SD)mg/dl [15]
PCOS Serum 6.93 ± 3.51(SD) mg/dl a
Women Healthy fertile Serum 3.1 ± 0.01 mg/dl [27]
Infertile Serum 4.7 ± 0.08 mg/dl a
Women Healthy fertile Follicular Fluid 3.5 ± 0.03 mg/dl [27]
Infertile Follicular Fluid 6.0 ± 0.1 a mg/dl
  1. a, significantly different levels as indicated by authors; SD standard deviation, SEM standard error of the mean