Non-esterified fatty acids in the ovary: friends or foes?

Table 1 Concentrations of NEFAs in different metabolic diseases in humans

Species	Condition	Biofluid	Concentration of NEFA	Ref.
Women	Obese non-diabetic	Plasma	290 μM	[24]
Women	Obese type 2 Diabetes	Plasma	621 μM ^a	[24]
Human (sex not defined)	Healthy	Plasma	0.18 ± 0.09 (SD) g/L	[25]
Human (sex not defined)	Type 2 Diabetes	Plasma	0.45 ± 0.21 (SD) g/L	[25]
Women	Normal weight	Follicular Fluid	0.22 ± 0.02 (SD) mM	[12]
	Overweight	Follicular Fluid	0.24 ± 0.03 (SD) mM
	Obese	Follicular Fluid	0.31 ± 0.08 (SD) mM ^a
Women	18.5 ≤ BMI ≤24.9 (n = 60)	Serum	0.60 ± 0.20 (SD) mM	[16]
	25.0 ≤ BMI ≤29.9 (n = 26)	Serum	0.70 ± 0.23 (SD) mM
	BMI ≥30.0 (n = 20)	Serum	0.70 ± 0.20 (SD) mM
Women	Non Obese	Follicular Fluid	0.16 ± 0.02 (SEM) meq/L	[26]
	Obese	Follicular Fluid	0.38 ± 0.04 (SEM) meq/L ^a
Women	Non Obese	Plasma	0.49 ± 0.22 (SD) mM	[13]
	Obese	Plasma	0.37 ± 0.18 (SD) mM
	PCOS Non Obese	Plasma	0.49 ± 0.23 (SD) mM
	PCOS Obese	Plasma	0.70 ± 0.13 (SD) mM ^a
Women	Healthy Control	Serum	4.36 ± 2.52 (SD)mg/dl	[15]
Women	PCOS	Serum	6.93 ± 3.51(SD) mg/dl ^a	[15]
Women	Healthy fertile	Serum	3.1 ± 0.01 mg/dl	[27]
Women	Infertile	Serum	4.7 ± 0.08 mg/dl ^a	[27]
Women	Healthy fertile	Follicular Fluid	3.5 ± 0.03 mg/dl	[27]
Women	Infertile	Follicular Fluid	6.0 ± 0.1 ^a mg/dl	[27]

^a, significantly different levels as indicated by authors; SD standard deviation, SEM standard error of the mean

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