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Fig. 5 | Reproductive Biology and Endocrinology

Fig. 5

From: Downregulation of hsa_circ_0005243 induces trophoblast cell dysfunction and inflammation via the β-catenin and NF-κB pathways

Fig. 5

Potential mechanisms of hsa_circ_0005243 regulation of trophoblast cell function and inflammatory factor expression. a Following knockdown of hsa_circ_0005243 in HTR-8/SVneo cells, the expression of β-catenin, c-myc, cyclin D1, and survivin were measured by Western blot. b Quantitative analysis of protein expression. c, d The expression of p65 protein in the nucleus was elevated after hsa_circ_0005243 knockdown. e Confocal immunofluorescence analysis showed that depletion of hsa_circ_0005243 was associated with an increase in NF-kB p65 subunit nuclear translocation. Data are presented as the mean ± SD, **p < 0.01

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