Increased risk of maternal and neonatal complications in hormone replacement therapy cycles in frozen embryo transfer

Table 3 Univariate and multivariate logistic regression model about NC, HRT and OI protocols

	Crude OR (95% Cl)	P-value	Adjusted OR (95% Cl)	P-value
HDP
NC	1		1
HRT	2.36 (1.86–2.99)	< 0.001^*	2.00 (1.54–2.60)	< 0.001^*
OI	1.34 (0.86–2.07)	0.193	1.02 (0.62–1.65)	0.853
GDM
NC	1		1
HRT	1.25 (0.99–1.58)	0.061	1.10 (0.84–1.45)	0.470
OI	1.48 (1.04–2.10)	0.028^*	1.49 (0.97–2.19)	0.056
Placenta previa
NC	1		1
HRT	1.48 (0.90–2.42)	0.122	1.52 (0.88–2.64)	0.133
OI	1.17 (0.50–2.75)	0.720	1.35 (0.55–3.27)	0.514
Oligohydramnios
NC	1		1
HRT	0.80 (0.47–1.37)	0.419	0.70 (0.40–1.24)	0.225
OI	1.36 (0.67–2.75)	0.399	1.06 (0.49–2.29)	0.887
PTB
NC	1		1
HRT	1.84 (1.47–2.30)	< 0.001^*	1.78 (1.39–2.28)	< 0.001^*
OI	1.76 (1.24–2.50)	0.002^*	1.51 (1.02–2.23)	0.041^*
LBW
NC	1		1
HRT	1.67 (1.25–2.23)	0.001^*	1.49 (1.09–2.06)	0.014^*
OI	1.35 (0.83–2.20)	0.231	1.17 (0.70–1.96)	0.547
SGA
NC	1		1
HRT	0.83 (0.60–1.15)	0.271	0.85 (0.60–1.21)	0.370
OI	1.46 (0.96–2.24)	0.078	1.47 (0.94–2.31)	0.092
LGA
NC	1		1
HRT	1.16 (1.02–1.33)	0.021^*	1.15 (0.99–1.33)	0.058
OI	0.93 (0.75–1.16)	0.505	0.98 (0.77–1.24)	0.842

NC natural cycle, HRT hormone replacement therapy, OI ovulation induction, OR odds ratio, CI confidence interval, HDP hypertensive disorders of pregnancy, GDM gestational diabetes mellitus, PTB preterm birth, LBW low birth weight, SGA small for gestational age, LGA large for gestational age
Adjustment included age, body mass index, irregular menstruation, donor sperm using, FET cycle number, number of transferred embryos, vanishing twin gestation, preconceptional fasting glucose, systolic pressure, diastolic pressure, endometrial thickness, antral follicle count, testosterone level, anti-Müllerian hormone
*There were significant differences between groups

ISSN: 1477-7827