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Table 1 The baseline characteristics of all participants

From: Increased risk of maternal and neonatal complications in hormone replacement therapy cycles in frozen embryo transfer

 NC
N = 4727
HRT
N = 1642
OI
N = 517
p-value
Maternal age (year)30.8 ± 4.030.5 ± 4.130.9 ± 4.10.109
BMI (kg/m2)22.5 ± 3.2a,b23.2 ± 3.422.8 ± 3.3< 0.001*
Indications for IVF
 Tubal factor2960 (62.6)1025 (62.4)325 (62.9)0.981
 Male factor1056 (22.3)356 (21.7)114 (22.1)0.856
 Combined factors566 (12.0)201 (12.2)60 (11.6)0.919
 Others145 (3.1)60 (3.7)18 (3.5)0.486
Irregular menstruation, n (%)267 (5.6)a,b359 (21.9)112 (21.7)< 0.001*
Donor sperm using, n (%)441 (9.3)131 (8.0)38 (7.4)0.115
FET cycle number1.2 ± 0.5a,b1.3 ± 0.6c1.6 ± 0.8< 0.001*
No.of transferred embryos, n (%)
  = 14138 (87.5)1455 (88.6)453 (87.6)0.516
  ≥ 2589 (12.5)187 (11.4)64 (12.4)0.516
Vanishing twin gestationd, n (%)143 (3.0)53 (3.2)13 (2.5)0.710
PFG (mmol/L)5.2 ± 0.5b5.2 ± 0.5c5.3 ± 0.50.002*
Systolic pressure (mmHg)119.5 ± 11.8a,b120.8 ± 11.6120.7 ± 11.9< 0.001*
Diastolic pressure (mmHg)71.7 ± 8.772.4 ± 8.673.3 ± 8.8< 0.001*
Endometrial thickness (mm)10.0 ± 1.6a,b9.5 ± 1.5c9.3 ± 1.7< 0.001*
AFC14.9 ± 5.9a15.6 ± 6.615.3 ± 6.0< 0.001*
Testosterone level (ng/dL)24.4 ± 11.7a,b26.0 ± 11.925.6 ± 12.5< 0.001*
AMHe (ng/mL)4.7 ± 3.7a5.3 ± 3.6c5.0 ± 3.5< 0.001*
  1. NC natural cycle, HRT hormone replacement therapy, OI ovulation induction, BMI body mass index, FET frozen embryo transfer, PFG preconceptional fasting glucose, AFC Antral follicle count, AMH anti-müllerian hormone
  2. *There were significant differences among the three groups
  3. aThere were significant differences between NC and HRT group
  4. bThere were significant differences between NC and OI group
  5. cThere were significant differences between HRT and OI group
  6. d5 of the patients underwent selective reduction of triplet or quadruplet pregnancy. 7 of the patients were of triplet pregnancy yet lost two fetuses spontaneously during early pregnancy
  7. eThere were data missing in AMH, including 430 in NC group and 122 in HRT group and 39 in OI group