Fig. 1

Changes in angiogenic gene expression in (a) GD10.5 and (b) GD16.5 implantation sites following CO exposure. (a) Kdr, Flt4, Tie2, Tek, Nos, Pecam1, Cdh5, Cx3cl1, and Efnb2 expression in GD10.5 implantation sites were upregulated in CO treated mice compared to controls (n = 5 control, n = 5 CO). (b) On GD16.5 there were no significant changes in gene expression (n = 5 control, n = 4 CO). A 2-fold change and a p value of 0.05 were used as cut off thresholds for significant changes in gene expression. Red represents elevated levels of gene expression and black no change. CO, carbon monoxide; GD, gestation day