Association of vascular endothelial growth factor polymorphisms with polycystic ovarian syndrome risk: a meta-analysis

Zhao, Jiahui; Li, Da; Tang, Huaiyun; Tang, Lisha

doi:10.1186/s12958-020-00577-0

Table 4 Main results of overall and subgroup analyses for VEGF polymorphisms and PCOS

From: Association of vascular endothelial growth factor polymorphisms with polycystic ovarian syndrome risk: a meta-analysis

Group/ Subgroup	Sample size (Case/Control)	Allele model			Dominant model			Heterozygote model			Recessive model			Homozygote model
Group/ Subgroup	Sample size (Case/Control)	OR (95%CI)	p	I²	OR (95%CI)	p	I²	OR (95%CI)	p	I²	OR (95%CI)	p	I²	OR (95%CI)	p	I²
rs2010963
Total	952/960	0.88 [0.76,1.01]	0.06	48%	0.78 [0.65, 0.94]	0.008	49%	0.75 [0.61, 0.91]	0.004	48%	1.03 [0.79, 1.36]	0.82	24%	0.88 [0.65, 1.17]	0.38	28%
Caucasian	519/548	0.99 [0.82, 1.20]	0.94	24%	0.98 [0.55, 1.73]	0.93	75%	0.93 [0.44, 1.96]	0.85	84%	1.41 [0.93, 2.12]	0.10	0%	1.17 [0.76, 1.80]	0.48	0%
Asian	433/412	0.76 [0.63, 0.93]	0.008	39%	0.69 [0.50, 0.95]	0.02	26%	0.68 [0.50, 0.92]	0.01	0%	0.80 [0.55, 1.16]	0.24	0%	0.68 [0.46, 1.02]	0.06	21%
PB	834/830	0.92 [0.79, 1.06]	0.24	45%	0.82 [0.68, 1.00]	0.29	48%	0.83 [0.59, 1.16]	0.27	51%	1.09 [0.81, 1.47]	0.56	29%	0.95 [0.69, 1.30]	0.73	24%
rs833061
Total	936/1010	0.98 [0.86, 1.12]	0.80	25%	0.93 [0.77,1.12]	0.45	6%	0.91 [0.74,1.11]	0.35	0%	1.06 [0.84,1.33]	0.63	0%	0.97 [0.75,1.26]	0.83	0%
Caucasian	637/698	0.99 [0.84, 1.15]	0.85	22%	0.93 [0.74,1.16]	0.51	0%	0.90 [0.71,1.15]	0.4	0%	1.06 [0.81,1.40]	0.66	27%	1.00 [0.73,1.35]	0.98	28%
Asian	299/312	0.96 [0.68, 1.37]	0.83	51%	0.90 [0.54,1.49]	0.67	54%	0.93 [0.64,1.33]	0.68	47%	1.05 [0.68,1.62]	0.84	0%	0.92 [0.57,1.48]	0.73	0%
PB	818/880	0.95 [0.83, 1.09]	0.48	10%	0.87 [0.71,1.07]	0.18	0%	0.85 [0.68,1.06]	0.14	0%	1.04 [0.82,1.32]	0.74	0%	0.94 [0.72,1.23]	0.63	0%
rs3025039
Total	779/834	0.97 [0.68, 1.39]	0.88	65%	1.07 [0.73, 1.57]	0.73	58%	1.21 [0.95, 1.55]	0.12	42%	0.59 [0.34, 1.02]	0.06	0%	0.56 [0.32, 0.99]	0.05	0%
Caucasian	500/543	1.22 [0.93, 1.60]	0.16	0%	1.35 [1.00, 1.83]	0.05	10%	1.43 [1.04, 1.95]	0.03	33%	0.70 [0.27, 1.82]	0.46	0%	0.76 [0.29, 1.97]	0.57	0%
Asian	269/236	0.79 [0.48, 1.29]	0.35	63%	0.83 [0.49, 1.41]	0.49	52%	0.94 [0.63, 1.39]	0.75	26%	0.54 [0.28, 1.05]	0.07	48%	0.48 [0.24, 0.97]	0.04	36%
PB	689/695	0.91 [0.60, 1.39]	0.68	71%	1.00 [0.63, 1.60]	0.99	66%	1.13 [0.72, 1.76]	0.60	55%	0.59 [0.34, 1.02]	0.06	0%	0.56 [0.32, 0.99]	0.05	0%
HWE (yes)	571/545	0.79 [0.50,1.25]	0.32	70%	0.84 [0.51,1.40]	0.51	63%	1.06 [0.79,1.41]	0.71	41%	0.58 [0.33,1.04]	0.07	4%	0.55 [0.30,0.99]	0.05	0%
rs699947
Total	779/834	1.03 [0.90, 1.19]	0.65	49%	1.03 [0.84, 1.26]	0.78	48%	1.01 [0.81, 1.26]	0.91	37%	1.07 [0.82, 1.38]	0.62	0%	1.06 [0.80, 1.41]	0.69	36%
Caucasian	724/782	1.00 [0.80, 1.25]	0.99	51%	1.07 [0.87, 1.32]	0.53	49%	1.05 [0.83, 1.31]	0.70	30%	1.09 [0.83, 1.43]	0.52	0%	1.11 [0.82, 1.51]	0.49	44%
rs1570360
Total	752/779	1.11 [0.95, 1.30]	0.20	0%	1.15 [0.94, 1.41]	0.17	11%	0.69 [0.37, 1.27]	0.23	82%	1.23 [0.89, 1.70]	0.21	15%	1.29 [0.92, 1.80]	0.14	13%
Caucasian	587/627	1.12 [0.94, 1.34]	0.19	0%	1.18 [0.94, 1.49]	0.14	0%	0.58 [0.24, 1.37]	0.21	88%	1.26 [0.88, 1.81]	0.21	40%	1.31 [0.90, 1.90]	0.16	23%
Asian	165/152	1.08 [0.53, 2.23]	0.83	73%	1.11 [0.49, 2.53]	0.79	66%	0.95 [0.24, 3.81]	0.95	82%	1.12 [0.55, 2.30]	0.75	27%	1.22 [0.58, 2.57]	0.60	50%
PB	642/679	1.16 [0.98, 1.37]	0.08	0%	1.22 [0.98, 1.52]	0.07	0%	0.75 [0.35, 1.58]	0.44	84%	1.29 [0.92, 1.79]	0.14	13%	1.36 [0.96, 1.93]	0.08	0%
HWE (yes)	697/727	1.08 [0.91,1.27]	0.39	0%	1.12 [0.90,1.38]	0.30	8%	0.56 [0.29,1.09]	0.09	84%	1.19 [0.84,1.69]	0.32	33%	1.23 [0.85,1.76]	0.27	25%

VEGF vascular endothelial growth factor, PCOS polycystic ovary syndrome, OR odds ratio, CI confidence interval, NA not available, HB hospital-based, PB population-based. The bold values represent statistically significant differences

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