Skip to main content

Table 4 Main results of overall and subgroup analyses for VEGF polymorphisms and PCOS

From: Association of vascular endothelial growth factor polymorphisms with polycystic ovarian syndrome risk: a meta-analysis

Group/ SubgroupSample size (Case/Control)Allele modelDominant modelHeterozygote modelRecessive modelHomozygote model
OR (95%CI)pI2OR (95%CI)pI2OR (95%CI)pI2OR (95%CI)pI2OR (95%CI)pI2
rs2010963
Total952/9600.88 [0.76,1.01]0.0648%0.78 [0.65, 0.94]0.00849%0.75 [0.61, 0.91]0.00448%1.03 [0.79, 1.36]0.8224%0.88 [0.65, 1.17]0.3828%
Caucasian519/5480.99 [0.82, 1.20]0.9424%0.98 [0.55, 1.73]0.9375%0.93 [0.44, 1.96]0.8584%1.41 [0.93, 2.12]0.100%1.17 [0.76, 1.80]0.480%
Asian433/4120.76 [0.63, 0.93]0.00839%0.69 [0.50, 0.95]0.0226%0.68 [0.50, 0.92]0.010%0.80 [0.55, 1.16]0.240%0.68 [0.46, 1.02]0.0621%
PB834/8300.92 [0.79, 1.06]0.2445%0.82 [0.68, 1.00]0.2948%0.83 [0.59, 1.16]0.2751%1.09 [0.81, 1.47]0.5629%0.95 [0.69, 1.30]0.7324%
rs833061
Total936/10100.98 [0.86, 1.12]0.8025%0.93 [0.77,1.12]0.456%0.91 [0.74,1.11]0.350%1.06 [0.84,1.33]0.630%0.97 [0.75,1.26]0.830%
Caucasian637/6980.99 [0.84, 1.15]0.8522%0.93 [0.74,1.16]0.510%0.90 [0.71,1.15]0.40%1.06 [0.81,1.40]0.6627%1.00 [0.73,1.35]0.9828%
Asian299/3120.96 [0.68, 1.37]0.8351%0.90 [0.54,1.49]0.6754%0.93 [0.64,1.33]0.6847%1.05 [0.68,1.62]0.840%0.92 [0.57,1.48]0.730%
PB818/8800.95 [0.83, 1.09]0.4810%0.87 [0.71,1.07]0.180%0.85 [0.68,1.06]0.140%1.04 [0.82,1.32]0.740%0.94 [0.72,1.23]0.630%
rs3025039
Total779/8340.97 [0.68, 1.39]0.8865%1.07 [0.73, 1.57]0.7358%1.21 [0.95, 1.55]0.1242%0.59 [0.34, 1.02]0.060%0.56 [0.32, 0.99]0.050%
Caucasian500/5431.22 [0.93, 1.60]0.160%1.35 [1.00, 1.83]0.0510%1.43 [1.04, 1.95]0.0333%0.70 [0.27, 1.82]0.460%0.76 [0.29, 1.97]0.570%
Asian269/2360.79 [0.48, 1.29]0.3563%0.83 [0.49, 1.41]0.4952%0.94 [0.63, 1.39]0.7526%0.54 [0.28, 1.05]0.0748%0.48 [0.24, 0.97]0.0436%
PB689/6950.91 [0.60, 1.39]0.6871%1.00 [0.63, 1.60]0.9966%1.13 [0.72, 1.76]0.6055%0.59 [0.34, 1.02]0.060%0.56 [0.32, 0.99]0.050%
HWE (yes)571/5450.79 [0.50,1.25]0.3270%0.84 [0.51,1.40]0.5163%1.06 [0.79,1.41]0.7141%0.58 [0.33,1.04]0.074%0.55 [0.30,0.99]0.050%
rs699947
Total779/8341.03 [0.90, 1.19]0.6549%1.03 [0.84, 1.26]0.7848%1.01 [0.81, 1.26]0.9137%1.07 [0.82, 1.38]0.620%1.06 [0.80, 1.41]0.6936%
Caucasian724/7821.00 [0.80, 1.25]0.9951%1.07 [0.87, 1.32]0.5349%1.05 [0.83, 1.31]0.7030%1.09 [0.83, 1.43]0.520%1.11 [0.82, 1.51]0.4944%
rs1570360
Total752/7791.11 [0.95, 1.30]0.200%1.15 [0.94, 1.41]0.1711%0.69 [0.37, 1.27]0.2382%1.23 [0.89, 1.70]0.2115%1.29 [0.92, 1.80]0.1413%
Caucasian587/6271.12 [0.94, 1.34]0.190%1.18 [0.94, 1.49]0.140%0.58 [0.24, 1.37]0.2188%1.26 [0.88, 1.81]0.2140%1.31 [0.90, 1.90]0.1623%
Asian165/1521.08 [0.53, 2.23]0.8373%1.11 [0.49, 2.53]0.7966%0.95 [0.24, 3.81]0.9582%1.12 [0.55, 2.30]0.7527%1.22 [0.58, 2.57]0.6050%
PB642/6791.16 [0.98, 1.37]0.080%1.22 [0.98, 1.52]0.070%0.75 [0.35, 1.58]0.4484%1.29 [0.92, 1.79]0.1413%1.36 [0.96, 1.93]0.080%
HWE (yes)697/7271.08 [0.91,1.27]0.390%1.12 [0.90,1.38]0.308%0.56 [0.29,1.09]0.0984%1.19 [0.84,1.69]0.3233%1.23 [0.85,1.76]0.2725%
  1. VEGF vascular endothelial growth factor, PCOS polycystic ovary syndrome, OR odds ratio, CI confidence interval, NA not available, HB hospital-based, PB population-based. The bold values represent statistically significant differences