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Table 1 Characteristics of included studies

From: Association of vascular endothelial growth factor polymorphisms with polycystic ovarian syndrome risk: a meta-analysis

AuthorYearRegionEthnicityPCOS Diagnostic criteriaInclusion criteria for the control groupControl sourceGenotyping methodSNPNOS
Almawi [20]2016BahrainCaucasianRotterdamage-and ethnically-matched; testosterone levels were within range (0.4–3.5 nmol/L) in the menstrual cycle follicular phase; no metabolic or endocrine diseases; BMI were between 18 and 45 kg/m2;without recent illness; without treatment may affect carbohydrate metabolism or hormonal levels within 3 months; without using anti-hypertensive, oral contraceptive, anti-inflammatory and lipid-lowering drugsPBRT-PCRrs2010963
rs833061
rs3025039
rs699947
rs1570360
8
Bao [21]2019IndiaAsianRotterdamage-and ethnically-matched; testosterone levels were within range (0.4–3.5 nmol/L) in the menstrual cycle follicular phase; no metabolic or endocrine diseases; BMI were between 18 and 45 kg/m2;without recent illness; without using anti-hypertensive, oral contraceptive, anti-inflammatory and lipid-lowering drugsPBRT-PCRrs2010963
rs833061
rs3025039
rs699947
rs1570360
6
Ben Salem [22]2016TunisiaCaucasianRotterdamwomen with regular menstrual cycles and no evidence of hirsutism, acne, alopecia, or endocrinopathies; without treatment may affect carbohydrate metabolism or hormonal levels within 3 monthsPBRT-PCRrs833061
rs3025039
rs699947
rs1570360
7
Ding [28]2009ChinaAsianRotterdamwomen with regular menstrual cycles; with normal ovarian morphology; without treatment may affect carbohydrate metabolism or hormonal levels within 3 months; no metabolic or endocrine diseases;HBPCRrs30250396
Gomes [23]2019BrazilCaucasianRotterdamage- matched; fertile women with no history of hyperandrogenism, menstrual dysfunction, infertility, or sonographic signal of PCOS; without using contraceptives, antiandrogens, statins, glucocorticoids or infertility medications within 6 monthsPBPCR-RFLP
(rs699947)
RT-PCR
(rs1570360)
rs699947
rs1570360
6
Guruvaiah [24]2014IndiaAsianRotterdamfertile women with regular menstrual cycles and had a successful pregnancy record; with normal ovarian morphology confirmed by ultrasoundPBPCRrs2010963
rs833061
7
Huang [25]2019ChinaAsianRotterdamwomen with normal menstrual cycles and had at least one successful pregnancy history; without endocrine disorders, family history of diabetes or sonographic signs of PCOSHBPCR-LDRrs2010963
rs833061
7
Lee [26]2008KoreaAsianRotterdamBMI-matched; with regular menstrual cycles; with normal ovarian morphology confirmed by ultrasoundPBPCRrs2010963
rs3025039
6
Li [29]2014ChinaAsianRotterdamfertile women with regular menstrual cyclesHBPCR-RFLPrs15703606
Vural [27]2009TurkeyCaucasianRotterdamfertile women without hyperandrogenism, history of menstrual dysfunction, infertility or sonographic signs of PCOS.PBPCRrs2010963
rs833061
rs699947
6
  1. PCR polymerase chain reaction, RFLP restriction fragment length polymorphism, RT-PCR real time polymerase chain reaction, PCR-LDR polymerase chain reaction-ligase detection reaction, NOS Newcastle–Ottawa scale, PB Population-based, HB Hospital-based, BMI body mass index, PCOS polycystic ovary syndrome