Table 1 Characteristics of included studies
Author | Year | Region | Ethnicity | PCOS Diagnostic criteria | Inclusion criteria for the control group | Control source | Genotyping method | SNP | NOS |
|---|---|---|---|---|---|---|---|---|---|
Almawi [20] | 2016 | Bahrain | Caucasian | Rotterdam | age-and ethnically-matched; testosterone levels were within range (0.4–3.5 nmol/L) in the menstrual cycle follicular phase; no metabolic or endocrine diseases; BMI were between 18 and 45 kg/m2;without recent illness; without treatment may affect carbohydrate metabolism or hormonal levels within 3 months; without using anti-hypertensive, oral contraceptive, anti-inflammatory and lipid-lowering drugs | PB | RT-PCR | rs2010963 rs833061 rs3025039 rs699947 rs1570360 | 8 |
Bao [21] | 2019 | India | Asian | Rotterdam | age-and ethnically-matched; testosterone levels were within range (0.4–3.5 nmol/L) in the menstrual cycle follicular phase; no metabolic or endocrine diseases; BMI were between 18 and 45 kg/m2;without recent illness; without using anti-hypertensive, oral contraceptive, anti-inflammatory and lipid-lowering drugs | PB | RT-PCR | rs2010963 rs833061 rs3025039 rs699947 rs1570360 | 6 |
Ben Salem [22] | 2016 | Tunisia | Caucasian | Rotterdam | women with regular menstrual cycles and no evidence of hirsutism, acne, alopecia, or endocrinopathies; without treatment may affect carbohydrate metabolism or hormonal levels within 3 months | PB | RT-PCR | rs833061 rs3025039 rs699947 rs1570360 | 7 |
Ding [28] | 2009 | China | Asian | Rotterdam | women with regular menstrual cycles; with normal ovarian morphology; without treatment may affect carbohydrate metabolism or hormonal levels within 3 months; no metabolic or endocrine diseases; | HB | PCR | rs3025039 | 6 |
Gomes [23] | 2019 | Brazil | Caucasian | Rotterdam | age- matched; fertile women with no history of hyperandrogenism, menstrual dysfunction, infertility, or sonographic signal of PCOS; without using contraceptives, antiandrogens, statins, glucocorticoids or infertility medications within 6 months | PB | PCR-RFLP (rs699947) RT-PCR (rs1570360) | rs699947 rs1570360 | 6 |
Guruvaiah [24] | 2014 | India | Asian | Rotterdam | fertile women with regular menstrual cycles and had a successful pregnancy record; with normal ovarian morphology confirmed by ultrasound | PB | PCR | rs2010963 rs833061 | 7 |
Huang [25] | 2019 | China | Asian | Rotterdam | women with normal menstrual cycles and had at least one successful pregnancy history; without endocrine disorders, family history of diabetes or sonographic signs of PCOS | HB | PCR-LDR | rs2010963 rs833061 | 7 |
Lee [26] | 2008 | Korea | Asian | Rotterdam | BMI-matched; with regular menstrual cycles; with normal ovarian morphology confirmed by ultrasound | PB | PCR | rs2010963 rs3025039 | 6 |
Li [29] | 2014 | China | Asian | Rotterdam | fertile women with regular menstrual cycles | HB | PCR-RFLP | rs1570360 | 6 |
Vural [27] | 2009 | Turkey | Caucasian | Rotterdam | fertile women without hyperandrogenism, history of menstrual dysfunction, infertility or sonographic signs of PCOS. | PB | PCR | rs2010963 rs833061 rs699947 | 6 |