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Table 2 Previous studies on secular trends in serum testosterone in men

From: Secular trends in testosterone- findings from a large state-mandate care provider

Source

Design

N

Period

Parameters adjusted for

Is age-adjusted decline significant?

before adjustment

after adjustment

Perheentupa et al. 2013 [7]

Observational, Finnish National Public Health Institute

3271

1972ā€“2002

BMI

Yes

Yes

Mazur et al. 2013 [9]

Longitudinal cohort. US Air-Force veterans

991

1982ā€“2002

BMI

Yes

Yes

Andersson et al. 2007 [6]

Population surveys at Glostrup Uni. Hosp., Denmark

5350

1982ā€“2001

BMI

Yes

No

Travison et al. 2007 [5]

Random sample MA, USA

1532

1987ā€“2004

BMI, smoking, medications, chronic illnesses, employment, marital status, general health

Yes*

Yes

Nyante et al. 2012 [4]

Observational NHANES participants

2315

1988ā€“2004

BMI\body fat, waist circumference, ethnicity, alcohol use, smoking, chronic illnesses, general health, medications

Yes

No

Walsh et al. 2015 [10]

Observational. VA HCS, Pacific NW

44,762

2002ā€“2011

None

Yes

NA**

  1. *Age matched trend of approx.-1.2% per year **Not calculated. Among tested patients, there was an observed monotonous increase in the proportion of patients with low T level from 35% in 2002 to 47.3% in 2011. ** An increase in SHBG remained significant. NHANES National Health and Nutrition Examination Survey; VA Veterans Affairs