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Table 2 Previous studies on secular trends in serum testosterone in men

From: Secular trends in testosterone- findings from a large state-mandate care provider

SourceDesignNPeriodParameters adjusted forIs age-adjusted decline significant?
before adjustmentafter adjustment
Perheentupa et al. 2013 [7]Observational, Finnish National Public Health Institute32711972–2002BMIYesYes
Mazur et al. 2013 [9]Longitudinal cohort. US Air-Force veterans9911982–2002BMIYesYes
Andersson et al. 2007 [6]Population surveys at Glostrup Uni. Hosp., Denmark53501982–2001BMIYesNo
Travison et al. 2007 [5]Random sample MA, USA15321987–2004BMI, smoking, medications, chronic illnesses, employment, marital status, general healthYes*Yes
Nyante et al. 2012 [4]Observational NHANES participants23151988–2004BMI\body fat, waist circumference, ethnicity, alcohol use, smoking, chronic illnesses, general health, medicationsYesNo
Walsh et al. 2015 [10]Observational. VA HCS, Pacific NW44,7622002–2011NoneYesNA**
  1. *Age matched trend of approx.-1.2% per year **Not calculated. Among tested patients, there was an observed monotonous increase in the proportion of patients with low T level from 35% in 2002 to 47.3% in 2011. ** An increase in SHBG remained significant. NHANES National Health and Nutrition Examination Survey; VA Veterans Affairs