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Table 6 Bisphenol A and PCOS

From: Bisphenol A: an emerging threat to female fertility

 SourceStrainAgeExposure routeTime of exposureDosesTime of observationOutcomeOutcome observed inReference n° 
Experimental studies in vitro and ex vivoHumanGranulosa-lutein cells33.8 ± 4.5 yearsIn vitro administration72 h1; 100; 1000; 10,000 ng/mL72 hIncrease of MMP9 levels at 100 and 1000 ng/mL concentrations. Decrease of MMP9 levels at 10000 ng/mL concentration. Decrease of cell viability at 1000 and 10,000 ng/mL concentrations. Dominguez 2008[124]
Experimental studies in vivoRatsSprague-DawleyFemale pupsSubcutaneous injectionFrom PND1 to PND105, 50 and 500 μg/kg bw/day4–5 months of ageIncrease of Testosterone and Estradiol levels and decrease of Progesterone levels in adulthood. Altered GnRH secretion in adulthood. Altered ovarian morphology, increase in cysts number and infertility at 500 μg/kg bw/day. Reduced fertility at 50 μg/kg bw/day. Infertility at 500 μg/kg bw/day.Adult femaleFernandez 2010[80]
RatsWistarFemale pupsDrinking waterFrom GD6 to PND401 mg/LPND40Induction of PCOS hallmarks.Pubertal femalePatisaul 2014[125]