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Table 6 Bisphenol A and PCOS

From: Bisphenol A: an emerging threat to female fertility

  Source Strain Age Exposure route Time of exposure Doses Time of observation Outcome Outcome observed in Reference n°  
Experimental studies in vitro and ex vivo Human Granulosa-lutein cells 33.8 ± 4.5 years In vitro administration 72 h 1; 100; 1000; 10,000 ng/mL 72 h Increase of MMP9 levels at 100 and 1000 ng/mL concentrations. Decrease of MMP9 levels at 10000 ng/mL concentration. Decrease of cell viability at 1000 and 10,000 ng/mL concentrations.   Dominguez 2008 [124]
Experimental studies in vivo Rats Sprague-Dawley Female pups Subcutaneous injection From PND1 to PND10 5, 50 and 500 μg/kg bw/day 4–5 months of age Increase of Testosterone and Estradiol levels and decrease of Progesterone levels in adulthood. Altered GnRH secretion in adulthood. Altered ovarian morphology, increase in cysts number and infertility at 500 μg/kg bw/day. Reduced fertility at 50 μg/kg bw/day. Infertility at 500 μg/kg bw/day. Adult female Fernandez 2010 [80]
Rats Wistar Female pups Drinking water From GD6 to PND40 1 mg/L PND40 Induction of PCOS hallmarks. Pubertal female Patisaul 2014 [125]