Fig. 2

The effect of BPA in the pathogenesis of PCOS. BPA may play a part in the development of PCOS through its steroid potential that can blunt hypothalamic-pituitary-ovarian axis functions by disrupting the steroidal feedbacks at the hypothalamus and pituitary level and steroid action at the level of the ovary. Further, BPA promotes an inflammatory milieu through adipose tissue having a direct action on adipocytes and macrophages infiltrating the adipose tissue and thus contributing to the onset of insulin resistance and compensatory hyperinsulinemia. In turn insulin worsens amplitude and frequency of GnRH and LH pulse secretion seen in PCOS