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Table 2 Studies on estrogen receptor (ER) and progesterone receptor (PGR), and their subtypes in eutopic endometrium during ovarian endometriosisa

From: An assessment of the multifactorial profile of steroid-metabolizing enzymes and steroid receptors in the eutopic endometrium during moderate to severe ovarian endometriosis

Reference[No.]Type of endometriosis [sample type and size]Major technique(s) usedSalient observations with remarks
Lessey et al., 1989 [20]PE, OE, DIE [CE (n = 25), EE (n = 12), EC (n = 9)]IHCNo difference was observed in the ER and PGR levels between CE and EE, as well as, between EE and EC. Analysis between CE and EE was not done based on phases of menstrual cycle despite tissue samples were collected during both cycle phases. Fertility history was not provided.
Burney et al., 2007 [10]PE, OE [CE (n = 16), EE (n = 21)]Microarray qRTPCR2.3-fold downregulation of PGR mRNA was observed in EE compared to CE. Analysis between CE and EE was not done based on phases of menstrual cycle despite tissue samples were collected during both phases of menstrual cycle. Fertility history was not provided.
Bukulmez et al., 2008 [21]PE, OE [CE (n = 8), EE (n = 12), EC (n = 14)]qRTPCR, IHC, WBLower ESR1:ESR2 mRNA ratio was observed in CE and EE than EC along with higher immunopositivity for ERβ
in EC. Lower PRA and PRB was observed in EC as compared to EE and CE. Analysis based on phases of menstrual cycle was not reported despite tissue samples were collected during both cycle phases. No information on stages of endometriosis and fertility history was provided.
Cavallini et al., 2011 [22]OE [CE (n = 10), EE_EC (n = 10)]qRTPCR, ELISA, IHCProtein expression of ERα was higher in EE than CE and EC with similar expressions in mRNA profiles. Protein expression of ERβ was lower in EE than EC and CE. Higher PGR mRNA and immunopositivity was observedin EE than in EC. No data for stages of endometriosis, phases of menstrual cycle and fertility history was provided.
Huhtinen et al., 2012 [12]PE, OE, DIE [CE (n = 15), EE (n = 37), EC (n = 41)]qRTPCRESR1 mRNA expression was lower in both phases of menstrual cycle in EC than CE. ESR1 mRNA was found to be lower in secretory phase as compared to proliferative phase in EE. ESR2 mRNA was higher in EC (OE and DIE) than CE in both phases. No data for stages of endometriosis and fertility history was provided.
  1. astudies which did not (i) mention specifically the types of endometriosis, (ii) include CE as well as EE samples, (iii) include OE samples were not selected. CE Control endometrium, DIE Deep infiltrating endometriosis, EC Ectopic lesion, EE Eutopic endometrium. EE_EC Autologous eutopic and ectopic tissues, IHC Immunohistochemistry, OE Ovarian endometriosis, PE Peritoneal endometriosis, qRTPCR quantitative real time PCR, WB Western blotting