Fig. 9
From: Ovulatory signals alter granulosa cell behavior through YAP1 signaling
Working model demonstrating the regulation of Hippo signaling during ovulation. Brefore the LH surge, cumulus cells are under the influence of oocyte factors that signal in part through SMAD2/3 mediated pathways to suppress Hippo pathway components and therefore activate YAP1 which stimulates proliferation and/or survival while blocking differentiation. After the LH surge and induction of EGF-like peptides, the Hippo pathway is transiently activated followed by YAP1 degradation which allows cumulus cells to terminally differentiate