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Table 1 The characteristics of included studies

From: Effects of FSHR polymorphisms on premature ovarian insufficiency in human beings: a meta-analysis

First author, year Country Ethnicity Age (years)
Case/Control
Sample size
Case/Control
Genotype distribution P-value for HWE NOS score
Cases Controls
rs6165 A/G
 Bretherick 2008 Canada Mixed 35.5/35.0 55/105 NA NA NA 7
 Conway 1999 UK Caucasian NA/NA 49/51 NA NA NA 7
 Cordts 2015 Brazil Mixed 31.0/31.0 96/123 29/48/19 55/53/15 0.687 7
 da Fonte Kohek 1998 Brazil Mixed 22.2/31.0 15/42 3/8/4 13/24/5 0.228 7
 Du 2010 China Asian NA/NA 40/92 20/18/2 40/37/15 0.207 7
 Ghezelayagh 2018 Iran Mixed NA/NA 84/80 24/50/10 28/48/4 0.004 8
 Juárez-Rendón 2018 Mexico Mixed 30.0/27.0 20/50 8/10/2 26/17/7 0.147 8
 Liu 1998 Germany Caucasian NA/NA 5/4 2/3/0 3/1/0 0.775 7
 Ma 2015 China Asian 29.8/29.3 63/58 33/25/5 28/25/5 0.861 7
 Sudo 2002 Japan Asian 32.9/31.3 17/163 NA NA NA 7
 Sundblad 2004 Argentina Caucasian 27.0/27.2 15/44 NA NA NA 7
 Tong 2001 Singapore Asian 24.9/25.4 16/236 2/13/1 102/110/24 0.475 8
 Vilodre 2008 Brazil Mixed NA/NA 35/42 9/19/7 13/24/5 0.228 7
 Woad 2013 New Zealand Caucasian NA/NA 80/80 28/34/18 25/38/17 0.718 7
rs6166 A/G
 Bretherick 2008 Canada Mixed 35.5/35.0 55/105 NA NA NA 7
 Conway 1999 UK Caucasian NA/NA 49/51 NA NA NA 7
 Cordts 2015 Brazil Mixed 31.0/31.0 96/123 30/52/14 34/68/21 0.190 7
 da Fonte Kohek 1998 Brazil Mixed 22.2/31.0 15/42 5/7/3 13/24/5 0.228 7
 Du 2010 China Asian NA/NA 37/90 16/19/2 40/34/16 0.077 7
 Kim 2011 South Korea Asian NA/NA 83/176 23/51/9 67/89/20 0.238 7
 Ma 2015 China Asian 29.8/29.3 63/58 31/30/2 32/22/4 0.934 7
 Sudo 2002 Japan Asian 32.9/31.3 17/168 NA NA NA 7
 Sundblad 2004 Argentina Caucasian 27.0/27.2 15/44 NA NA NA 7
 Tong 2001 Singapore Asian 24.9/25.4 16/236 5/11/0 91/132/13 < 0.001 8
 Vilodre 2008 Brazil Mixed NA/NA 35/42 15/15/5 13/24/5 0.228 7
 Woad 2013 New Zealand Caucasian NA/NA 80/80 29/33/18 26/37/17 0.572 7
 Yin 2016 China Asian 31.3/29.2 79/118 25/37/17 43/45/30 0.013 8
  1. Abbreviations: HWE Hardy-Weinberg equilibrium, NOS Newcastle-Ottawa scale, NA Not available