From: Segmental aneuploidy in human blastocysts: a qualitative and quantitative overview
Clinical indication (n) | Number of euploid blastocysts (n, %) | Number of aneuploid blastocysts (n, %) with: | ||||
---|---|---|---|---|---|---|
One or more whole-chromosome aneuploidies* | Segmental aneuploidy | |||||
Without whole-chromosome aneuploidies associated | With one or more whole-chromosome aneuploidies associated | |||||
One segmental aneuploidy (SSA) | > 1 segmental aneuploidy | One segmental Aneuploidy | > 1 segmental aneuploidy | |||
Recurrent miscarriage (453) | 245 (54.1) a | 169 (37.3) b | 21 (4.6) | 4 (0.9) | 13 (2.9) | 1 (0.2) |
Advanced maternal age (1778) | 623 (35.0) b | 1011 (56.9) a | 67 (3.8) | 3 (0.2) | 67 (3.8) | 7 (0.4) |
Prior chromosome pathology (208) | 126 (60.6) a,c | 66 (31.7) b,c | 12 (5.8) | 0 | 4 (1.9) | 0 |
Male factor (457) | 293 (64.1) c | 127 (27.8) c | 22 (4.8) | 3 (0.6) | 11 (2.4) | 1 (0.2) |
Implantation failure (570) | 314 (55.1) a | 207 (36.3) b | 27 (4.7) | 3 (0.5) | 17 (2.9) | 2 (0.3) |
Sperm aneuploidy (99) | 55 (55.6) a,c | 30 (30.3) b,c | 10 (10.1) | 0 | 3 (3.0) | 1 (1.0) |
Total (3565) | 1656 (46.4) | 1610 (45.2) | 159 (4.5) | 13 (0.4) | 115 (3.2) | 12 (0.3) |