From: New Frontiers in IVF: mtDNA and autologous germline mitochondrial energy transfer
 | Study design | Number total embryos and blastocysts analysed | Differences in mtDNA quantity in implanted vs non implanted pregnancies | Differences in mtDNA quantity in euploid vs aneuploid pregnancies | Differences in mtDNA quantity in poor vs good embryo morphology |
---|---|---|---|---|---|
Fraguoli et al., 2015 [14] | OP | 379 | lower amount of mtDNA (p = 0.007) | lower amounts of mtDNA (p = 0.006) | N/A |
Diez-Juan et al., 2015 [50] | OR | 27027 | lower amount of mtDNA (p < 0.02) | N/A | not statistically significant |
Victor et al., 2017 [59] | OR | 1396 | not statistically significant | not statistically significant | N/A |
Ravichandran et al., 2017 [60] | OR | 1505 | lower amount of mtDNA (p = 0.030) | N/A | N/A |
Fraguoli et al., 2017 | OP | 199 | lower/normal amount of mtDNA (p < 0.0001) | N/A | N/A |
Treff et al., 2017 [62] | OR | 374 | not statistically significant | N/A | N/A |
Klimczak et al., 2018 [63] | OR | 1510 | not statistically significant |  | higher amount of mtDNA (P = 0.003) |
De los Santos et al., 2018 [61] | OR | 465 | N/A | lower amount of mtDNA (p < 0.001) | higher amount of mtDNA (p < 0.03) * |