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Table 1 Investigation of mtDNA in human preimplantation embryos/blastocysts which had successfully reached the blastocyst stage of development:correlations between the amount of mtDNA and implantation rate, aneuploidy rate, and morphology of the embryo. The studies were heterogeneous: each study used specific selected samples, statistical tests and sub analysis of results

From: New Frontiers in IVF: mtDNA and autologous germline mitochondrial energy transfer

 

Study design

Number total embryos and blastocysts analysed

Differences in mtDNA quantity in implanted vs non implanted pregnancies

Differences in mtDNA quantity in euploid vs aneuploid pregnancies

Differences in mtDNA quantity in poor vs good embryo morphology

Fraguoli et al., 2015 [14]

OP

379

lower amount of mtDNA

(p = 0.007)

lower amounts of mtDNA

(p = 0.006)

N/A

Diez-Juan et al., 2015 [50]

OR

27027

lower amount of mtDNA (p < 0.02)

N/A

not statistically significant

Victor et al., 2017 [59]

OR

1396

not statistically significant

not statistically significant

N/A

Ravichandran et al., 2017 [60]

OR

1505

lower amount of mtDNA (p = 0.030)

N/A

N/A

Fraguoli et al., 2017

OP

199

lower/normal amount of mtDNA (p < 0.0001)

N/A

N/A

Treff et al., 2017 [62]

OR

374

not statistically significant

N/A

N/A

Klimczak et al., 2018 [63]

OR

1510

not statistically significant

 

higher amount of mtDNA (P = 0.003)

De los Santos et al., 2018 [61]

OR

465

N/A

lower amount of mtDNA (p < 0.001)

higher amount of mtDNA (p < 0.03) *

  1. OR observational retrospective, OP observational prospective
  2. *in euploid embryos