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Table 1 Investigation of mtDNA in human preimplantation embryos/blastocysts which had successfully reached the blastocyst stage of development:correlations between the amount of mtDNA and implantation rate, aneuploidy rate, and morphology of the embryo. The studies were heterogeneous: each study used specific selected samples, statistical tests and sub analysis of results

From: New Frontiers in IVF: mtDNA and autologous germline mitochondrial energy transfer

  Study design Number total embryos and blastocysts analysed Differences in mtDNA quantity in implanted vs non implanted pregnancies Differences in mtDNA quantity in euploid vs aneuploid pregnancies Differences in mtDNA quantity in poor vs good embryo morphology
Fraguoli et al., 2015 [14] OP 379 lower amount of mtDNA
(p = 0.007)
lower amounts of mtDNA
(p = 0.006)
Diez-Juan et al., 2015 [50] OR 27027 lower amount of mtDNA (p < 0.02) N/A not statistically significant
Victor et al., 2017 [59] OR 1396 not statistically significant not statistically significant N/A
Ravichandran et al., 2017 [60] OR 1505 lower amount of mtDNA (p = 0.030) N/A N/A
Fraguoli et al., 2017 OP 199 lower/normal amount of mtDNA (p < 0.0001) N/A N/A
Treff et al., 2017 [62] OR 374 not statistically significant N/A N/A
Klimczak et al., 2018 [63] OR 1510 not statistically significant   higher amount of mtDNA (P = 0.003)
De los Santos et al., 2018 [61] OR 465 N/A lower amount of mtDNA (p < 0.001) higher amount of mtDNA (p < 0.03) *
  1. OR observational retrospective, OP observational prospective
  2. *in euploid embryos