From: Effect of vitamin D status on normal fertilization rate following in vitro fertilization
Parameter | Pregnant | Not pregnant | P value | Live birth | No live birth | P value |
---|---|---|---|---|---|---|
Number of cycles | 293 | 194 | Â | 261 | 226 | Â |
Age(y) | 31.29 ± 3.53 | 32.63 ± 3.65 | <0.001* | 31.12 ± 3.41 | 32.64 ± 3.71 | <0.001* |
Duration of infertility(y) | 3.54 ± 2.26 | 3.77 ± 2.43 | 0.284 | 3.45 ± 2.15 | 3.84 ± 2.52 | 0.065 |
BMI (kg/m2) | 23.25 ± 3.34 | 23.74 ± 3.46 | 0.116 | 23.28 ± 3.34 | 23.62 ± 3.46 | 0.271 |
AMH (ng/ml) | 5.31 ± 3.76 | 4.83 ± 3.55 | 0.160 | 5.41 ± 3.82 | 4.79 ± 3.50 | 0.065 |
bFSH (mIU/ml) | 6.98 ± 1.74 | 7.10 ± 1.88 | 0.475 | 6.93 ± 1.74 | 7.14 ± 1.87 | 0.208 |
Season of blood drawing | ||||||
 Spring (n, %) | 41,54.7% | 34,45.3% | 0.209 | 37,14.2% | 4,12.5% | 0.706 |
 Summer (n, %) | 83, 58.5% | 59,41.5% | 76,29.1% | 7,21.9% | ||
 Autumn (n, %) | 83,68.0% | 39,32.0% | 74,28.4% | 9,28.1% | ||
 Winter (n, %) | 86; 58.1% | 62,41.9% | 74,28.4% | 12,37.5% | ||
Previous pregnancy | ||||||
 NO (n, %) | 141, 48.1% | 89, 45.9% | 0.628 | 129,49.4% | 106,46.9% | 0.587 |
 Yes (n, %) | 152, 51.9% | 105, 54.1% | 132,50.6% | 120,53.1% | ||
Infertility diagnosis | ||||||
 Male factor (n, %) | 11,3.8% | 6,3.1% | 0.426 | 10,3.8% | 6,2.7% | 0.688 |
 Tubal factor (n, %) | 193,65.9% | 125,64.4% | 168,64.4% | 150,66.4% | ||
 Mixed (n, %) | 41,14.0% | 21,10.8% | 38,14.6% | 25,11.1% | ||
 Endometriosis (n, %) | 18,6.1% | 11, 5.7% | 16,6.1% | 12,5.3% | ||
 Anovulatory (n, %) | 28,9.6% | 27,13.9% | 26,10.0% | 29,12.8% | ||
 Unexplained (n, %) | 2,0.7% | 4,2.1% | 3,1.1% | 4,1.8% | ||
COH protocol | ||||||
 Luteal phase agonist (n, %) | 228,77.8% | 138,71.1% | 0.108 | 207,79.3% | 159,70.4% | 0.027* |
 Antagonist (n, %) | 65,22.2% | 56,28.9% | 54,20.7% | 67,29.6% | ||
Duration of stimulation (d) | 9.08 ± 2.31 | 9.05 ± 2.06 | 0.908 | 9.06 ± 2.26 | 9.07 ± 2.16 | 0.962 |
Follicle≥16 mm on HCG day | 7.74 ± 3.04 | 7.22 ± 2.96 | 0.059 | 7.78 ± 2.90 | 7.25 ± 3.13 | 0.055 |
Endometrial thickness on HCG day (mm) | 11.75 ± 2.10 | 11.22 ± 2.24 | 0.008* | 11.82 ± 2.09 | 11.21 ± 2.22 | 0.002* |
Progestrone on HCG day (ng/ml) | 0.92 ± 0.29 | 0.90 ± 0.33 | 0.578 | 0.92 ± 0.29 | 0.90 ± 0.33 | 0.332 |
Peak estradiol (pg/ml) | 2602.72 ± 1142.74 | 2436.73 ± 1032.56 | 0.116 | 2625.10 ± 1114.09 | 2436.06 ± 1078.48 | 0.070 |
Oocytes retrieved (n) | 8.39 ± 2.98 | 7.91 ± 3.28 | 0.094 | 8.50 ± 2.95 | 7.85 ± 3.25 | 0.020* |
Mature oocytes (n) | 7.03 ± 2.68 | 6.66 ± 2.99 | 0.156 | 7.15 ± 2.68 | 6.58 ± 2.92 | 0.024* |
Normal fertilization rate (%) | 72.55 ± 17.70 | 73.19 ± 20.05 | 0.710 | 72.22 ± 17.18 | 73.48 ± 20.23 | 0.456 |
High quality embryo rate (%) | 59.5% | 57.1% | 0.199 | 58.4% | 51.6% | 0.001* |
Blastocyst formation rate (%) | 66.33 ± 31.39 | 62.75 ± 34.51 | 0.273 | 66.06 ± 31.59 | 63.61 ± 33.90 | 0.443 |
Embryos transferred (n) | 1.96 ± 0.21 | 1.92 ± 0.28 | 0.082 | 1.96 ± 0.20 | 1.92 ± 0.27 | 0.081 |