From: Effect of vitamin D status on normal fertilization rate following in vitro fertilization
Parameter | Group1 | Group2 | Group 3 | Group 4 | P value |
---|---|---|---|---|---|
Number of cycles | 216 | 210 | 211 | 211 | Â |
Serum 25(OH) D (ng/ml) | |||||
 Median | 9.04 | 13.67 | 16.20 | 23.22 |  |
 Range | 4.92–11.20 | 11.25–14.00 | 14.10–18.60 | 18.70–39.51 |  |
Age(y) | 31.65 ± 3.32 | 31.86 ± 3.94 | 31.31 ± 3.44 | 31.88 ± 3.69 | 0.331 |
Duration of infertility(y) | 3.53 ± 2.19 | 3.85 ± 2.76 | 3.68 ± 2.31 | 3.61 ± 2.38 | 0.543 |
BMI (kg/m2) | 23.93 ± 3.61 | 23.37 ± 3.30 | 23.16 ± 3.28 | 23.46 ± 3.33 | 0.099 |
AMH (ng/ml) | 7.21 ± 5.50 | 6.05 ± 4.37 | 6.93 ± 5.61 | 6.68 ± 5.51 | 0.134 |
bFSH (mIU/ml) | 6.75 ± 1.77 | 7.04 ± 2.03 | 6.88 ± 1.95 | 6.57 ± 1.68 | 0.063 |
Season of blood drawing | |||||
 Spring (n, %) | 55,25.5% | 39,18.6% | 25,11.8% | 24,11.4% | <0.001* |
 Summer (n, %) | 78,36.1% | 71,33.8% | 55,26.1% | 41,19.4% | |
 Autumn (n, %) | 22,10.2% | 43,20.5% | 76,36.0% | 74,35.1% | |
 Winter (n, %) | 61,28.2% | 57,27.1% | 55,26.1% | 72,34.1% | |
Previous pregnancy | |||||
 NO (n, %) | 106 (49.1%) | 87 (41.4%) | 111 (52.6%) | 103 (48.8%) | 0.134 |
 Yes (n, %) | 110 (50.9%) | 123 (58.6%) | 100 (47.4%) | 108 (51.2%) | |
Infertility diagnosis | |||||
 Male factor (n, %) | 5 (2.3%) | 11 (5.2%) | 10 (4.7%) | 10 (4.7%) | 0.837 |
 Tubal factor (n, %) | 135 (62.8%) | 131 (62.4%) | 122 (57.8%) | 125 (59.2%) | |
 Mixed (n, %) | 24 (11.2%) | 28 (13.3%) | 26 (12.3%) | 28 (13.3%) | |
 Endometriosis (n, %) | 7 (3.3%) | 11 (5.2%) | 13 (6.2%) | 14 (6.6%) | |
 Anovulatory (n, %) | 41 (19.1%) | 27 (12.9%) | 37 (17.5%) | 32 (15.2%) | |
 Unexplained (n, %) | 3 (1.4%) | 2 (1.0%) | 3 (1.4%) | 2 (0.9%) | |
COH protocol | |||||
 Luteal phase agonist (n, %) | 151 (69.9%) | 143 (68.1%) | 159 (75.4%) | 158 (74.9%) | 0.250 |
 Antagonist (n, %) | 65 (30.1%) | 67 (31.9%) | 52 (24.6%) | 53 (25.1%) | |
Duration of stimulation (d) | 9.06 ± 2.17 | 9.04 ± 2.34 | 8.81 ± 2.20 | 9.05 ± 2.50 | 0.631 |
Follicle≥16 mm on HCG day | 10.26 ± 4.94 | 9.01 ± 4.73 | 9.86 ± 5.55 | 9.68 ± 5.02 | 0.083 |
Endometrial thickness on HCG day (mm) | 11.62 ± 2.71 | 11.30 ± 2.21 | 11.36 ± 2.32 | 11.49 ± 2.45 | 0.536 |
Progestrone on HCG day (ng/ml) | 0.86 ± 0.28 | 0.90 ± 0.29 | 0.94 ± 0.34 | 0.94 ± 0.32 | 0.143 |
Peak estradiol (pg/ml) | 3737.49 ± 2178.84 | 3398.98 ± 2227.44 | 3593.33 ± 2352.79 | 3569.79 ± 2231.67 | 0.540 |
Oocytes retrieved (n) | 11.47 ± 5.53 | 10.12 ± 4.78 | 10.79 ± 5.43 | 10.68 ± 5.56 | 0.078 |
Mature oocytes (n) | 9.45 ± 4.80 | 8.40 ± 4.14 | 9.05 ± 4.66 | 8.97 ± 4.54 | 0.119 |
Normal fertilization rate (%) | 69.62 ± 17.85 | 71.69 ± 19.92 | 73.82 ± 18.36 | 75.43 ± 17.39 | 0.007* <0.001a* |
High quality embryo rate (%) | 67.5% | 67.2% | 65.3% | 67.7% | 0.465 |
Blastocyst formation rate (%) | 66.86 ± 28.60 | 62.48 ± 33.21 | 65.84 ± 31.27 | 67.96 ± 28.87 | 0.332 |
Embryos transferred (n) | 1.93 ± 0.26 | 1.92 ± 0.28 | 1.97 ± 0.18 | 1.95 ± 0.22 | 0.340 |