From: IVF outcomes of women with discrepancies between age and serum anti-Müllerian hormone levels
Characteristic | Age<35 yrs | Age ≥ 35 yrs | ||||
---|---|---|---|---|---|---|
young low-AMH (N = 1819) | young average-AMH (N = 3642) | young high-AMH (N = 1822) | older low-AMH (N = 537) | older average-AMH (N = 1074) | older high-AMH (N = 537) | |
AMH range[%(ng/ml)] | 0-25th quartile (0.01–1.32) | 25th–75th quartile (1.32–3.99) | 75th–100th quartile (3.99–22.05) | 0-25th quartile (< 0.01–0.62) | 25th–75th quartile (0.63–2.41) | 75th–100th quartile (2.41–22.05) |
Age (yrs) | 29.46 ± 3.18 | 28.74 ± 3.16 | 28.26 ± 3.10 | 38.67 ± 2.90 | 37.88 ± 2.57 | 37.12 ± 2.16 |
BMI (kg/m2) | 23.12 ± 3.69 | 22.90 ± 3.42 | 22.82 ± 3.62 | 24.00 ± 3.15 | 24.11 ± 3.19 | 23.99 ± 3.29 |
AFC | 10.52 ± 4.78a,b | 14.46 ± 5.80c | 19.78 ± 9.41 | 7.14 ± 2.93d,e | 10.47 ± 5.38f | 15.18 ± 7.04 |
Fertility history | ||||||
Previous conception[%(n/N)] | 41.67(758/1819)g | 39.07(1423/3642) | 34.69(632/1822) | 72.75(388/537) | 74.77(803/1074) | 66.85(359/537) |
Concomitant infertility factors | ||||||
Tubal factors[%(n/N)] | 66.08(1202/1819)b | 64.74(2358/3642)c | 60.21(1097/1822) | 68.34(367/537) | 71.79(771/1074) | 70.58(379/537) |
Ovulatory dysfunction[%(n/N)] | ||||||
PCOS[%(n/N)] | 2.25(41/1819)a,b | 7.36(268/3642)c | 23.49(428/1822) | 0.56(3/537)e | 1.96(21/1074)f | 10.80(58/537) |
POI[%(n/N)] | 5.22(95/1819)a,b | 0.41(15/3642) | 0(0/0) | 8.39(45/537)d,e | 1.96(21/1074) | 0.19(1/537) |
Male factors[%(n/N)] | 30.90(562/1819)a,b | 36.55(1331/3642) | 37.87(690/1822) | 22.91(123/537) | 26.44(284/1074) | 25.14(135/537) |
Controlled Ovarian Hyperstimulation outcome | ||||||
Gonadotropin start dose (IU) | 196.40 ± 48.96a,b | 177.05 ± 44.02c | 162.95 ± 42.41 | 230.48 ± 49.82d,e | 218.14 ± 48.73f | 197.69 ± 41.29 |
Total Gonadotropin dose (IU) | 2130.27 ± 982.84g | 1937.00 ± 778.37 | 1782.24 ± 762.80 | 2375.30 ± 1108.22 | 2286.36 ± 970.59 | 2140.51 ± 800.74 |
No. of days of ovarian stimulation | 10.52 ± 2.02g | 10.82 ± 1.78 | 10.94 ± 1.95 | 10.06 ± 2.28 | 10.41 ± 2.03 | 10.85 ± 1.93 |
Endometrial thickness on hCG trigger day(cm) | 1.11 ± 0.20 | 1.13 ± 0.18 | 1.12 ± 0.18 | 1.02 ± 0.23d,e | 1.07 ± 0.20 | 1.10 ± 0.20 |