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Table 1 Characteristics of the Patients at Baseline According Age and AMH Level

From: IVF outcomes of women with discrepancies between age and serum anti-Müllerian hormone levels

Characteristic Age<35 yrs Age ≥ 35 yrs
young
low-AMH
(N = 1819)
young
average-AMH
(N = 3642)
young
high-AMH
(N = 1822)
older
low-AMH
(N = 537)
older
average-AMH
(N = 1074)
older
high-AMH
(N = 537)
AMH range[%(ng/ml)] 0-25th
quartile (0.01–1.32)
25th–75th
quartile (1.32–3.99)
75th–100th
quartile (3.99–22.05)
0-25th
quartile (< 0.01–0.62)
25th–75th
quartile (0.63–2.41)
75th–100th quartile (2.41–22.05)
Age (yrs) 29.46 ± 3.18 28.74 ± 3.16 28.26 ± 3.10 38.67 ± 2.90 37.88 ± 2.57 37.12 ± 2.16
BMI (kg/m2) 23.12 ± 3.69 22.90 ± 3.42 22.82 ± 3.62 24.00 ± 3.15 24.11 ± 3.19 23.99 ± 3.29
AFC 10.52 ± 4.78a,b 14.46 ± 5.80c 19.78 ± 9.41 7.14 ± 2.93d,e 10.47 ± 5.38f 15.18 ± 7.04
Fertility history
 Previous conception[%(n/N)] 41.67(758/1819)g 39.07(1423/3642) 34.69(632/1822) 72.75(388/537) 74.77(803/1074) 66.85(359/537)
Concomitant infertility factors
 Tubal factors[%(n/N)] 66.08(1202/1819)b 64.74(2358/3642)c 60.21(1097/1822) 68.34(367/537) 71.79(771/1074) 70.58(379/537)
Ovulatory dysfunction[%(n/N)]
 PCOS[%(n/N)] 2.25(41/1819)a,b 7.36(268/3642)c 23.49(428/1822) 0.56(3/537)e 1.96(21/1074)f 10.80(58/537)
 POI[%(n/N)] 5.22(95/1819)a,b 0.41(15/3642) 0(0/0) 8.39(45/537)d,e 1.96(21/1074) 0.19(1/537)
 Male factors[%(n/N)] 30.90(562/1819)a,b 36.55(1331/3642) 37.87(690/1822) 22.91(123/537) 26.44(284/1074) 25.14(135/537)
Controlled Ovarian Hyperstimulation outcome
 Gonadotropin start dose (IU) 196.40 ± 48.96a,b 177.05 ± 44.02c 162.95 ± 42.41 230.48 ± 49.82d,e 218.14 ± 48.73f 197.69 ± 41.29
 Total Gonadotropin dose (IU) 2130.27 ± 982.84g 1937.00 ± 778.37 1782.24 ± 762.80 2375.30 ± 1108.22 2286.36 ± 970.59 2140.51 ± 800.74
 No. of days of ovarian stimulation 10.52 ± 2.02g 10.82 ± 1.78 10.94 ± 1.95 10.06 ± 2.28 10.41 ± 2.03 10.85 ± 1.93
 Endometrial thickness on hCG trigger day(cm) 1.11 ± 0.20 1.13 ± 0.18 1.12 ± 0.18 1.02 ± 0.23d,e 1.07 ± 0.20 1.10 ± 0.20
  1. AMH anti-Müllerian hormone, BMI body Mass Index, AFC antral follicle count
  2. Continuous data was presented as mean ± standard deviation, and categorical variable was presented as percentile (number)
  3. Significant subgroup differences (Bonferroni pairwise comparison, p < 0.05/3) are indicated by superscripts “a: low AMH vs. average AMH in women < 35 yrs”, “b: low AMH vs. high AMH in women < 35 yrs”, “c: average AMH vs. high AMH in women < 35 yrs”, “d: low AMH vs. average AMH in women ≥35 yrs”, “e significant difference for low AMH vs. high AMH in women ≥35 yrs”,“f significant difference for average AMH vs. high AMH in women ≥35 yrs” g: p < 0.05 was considered statistically significant difference for main effect