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Table 2 Cluster of significant pathways related to IVF-ET

From: The placental transcriptome of the first-trimester placenta is affected by in vitro fertilization and embryo transfer

No Term ID Input number P-Value
1 Metabolic pathways hsa01100 279 7.43 × 10− 22
2 Complement and coagulation cascades hsa04610 44 5.74 × 10−14
3 Proteoglycans in cancer hsa05205 58 4.17 × 10−8
4 Pathways in cancer hsa05200 87 3.72 × 10−7
5 Insulin resistance hsa04931 33 1.08 × 10−5
6 Carbon metabolism hsa01200 33 1.46 × 10−5
7 Axon guidance hsa04360 44 2.23 × 10−5
8 Ras signaling pathway hsa04014 52 3.77 × 10−5
9 Glycine, serine and threonine metabolism hsa00260 17 4.59 × 10−5
10 Mineral absorption hsa04978 19 8.74 × 10−5
11 PPAR signaling pathway hsa03320 23 1.08 × 10−4
12 Wnt signaling pathway hsa04310 35 1.53 × 10− 4
13 Transcriptional misregulation in cancer hsa05202 41 1.72 × 10−4
14 AGE-RAGE signaling pathway in diabetic complications hsa04933 28 1.74 × 10−4
15 HIF-1 signaling pathway hsa04066 28 2.28 × 10−4
16 mTOR signaling pathway hsa04150 36 3.31 × 10−4
17 Fatty acid metabolism hsa01212 17 3.32 × 10−4
18 Focal adhesion hsa04510 44 3.81 × 10−4
19 Regulation of actin cytoskeleton hsa04810 46 3.91 × 10−4
20 Fatty acid degradation hsa00071 16 3.94 × 10−4
21 Steroid hormone biosynthesis hsa00140 19 3.94 × 10−4
22 Bile secretion hsa04976 21 4.29 × 10−4
23 Aldosterone-regulated sodium reabsorption hsa04960 15 4.65 × 10−4
24 Jak-STAT signaling pathway hsa04630 36 5.50 × 10−4
25 ErbB signaling pathway hsa04012 24 6.18 × 10−4
26 Steroid biosynthesis hsa00100 10 6.33 × 10−4
27 Valine, leucine and isoleucine degradation hsa00280 16 7.02 × 10−4
28 Renal cell carcinoma hsa05211 20 7.19 × 10−4
29 Biosynthesis of amino acids hsa01230 21 9.01 × 10−4
30 Tyrosine metabolism hsa00350 13 9.74 × 10−4
31 Tryptophan metabolism hsa00380 14 1.01 × 10−3
32 EGFR tyrosine kinase inhibitor resistance hsa01521 22 1.09 × 10−3
33 Cytokine-cytokine receptor interaction hsa04060 51 1.10 × 10−3
34 Arginine biosynthesis hsa00220 10 1.11 × 10− 3
35 Proximal tubule bicarbonate reclamation hsa04964 10 1.45 × 10−3
36 Sphingolipid metabolism hsa00600 15 1.46 × 10−3
37 Rap1 signaling pathway hsa04015 43 1.48 × 10−3
38 Hippo signaling pathway-multiple species hsa04392 11 1.64 × 10−3
39 FoxO signaling pathway hsa04068 30 1.79 × 10−3
40 Glycerolipid metabolism hsa00561 17 1.84 × 10−3
41 Vitamin digestion and absorption hsa04977 10 1.87 × 10−3
42 Pentose phosphate pathway hsa00030 11 2.05 × 10−3
43 cAMP signaling pathway hsa04024 40 2.13 × 10−3
44 AMPK signaling pathway hsa04152 28 2.26 × 10−3
45 Arginine and proline metabolism hsa00330 15 2.41 × 10−3
46 Alanine, aspartate and glutamate metabolism hsa00250 12 2.60 × 10−3
47 Epithelial cell signaling in Helicobacter pylori infection hsa05120 18 3.00 × 10−3
48 beta-Alanine metabolism hsa00410 11 3.13 × 10−3
49 Insulin signaling pathway hsa04910 30 3.13 × 10−3
50 Propanoate metabolism hsa00640 11 3.81 × 10−3