Table 2 Cluster of significant pathways related to IVF-ET
No | Term | ID | Input number | P-Value |
|---|---|---|---|---|
1 | Metabolic pathways | hsa01100 | 279 | 7.43 × 10− 22 |
2 | Complement and coagulation cascades | hsa04610 | 44 | 5.74 × 10−14 |
3 | Proteoglycans in cancer | hsa05205 | 58 | 4.17 × 10−8 |
4 | Pathways in cancer | hsa05200 | 87 | 3.72 × 10−7 |
5 | Insulin resistance | hsa04931 | 33 | 1.08 × 10−5 |
6 | Carbon metabolism | hsa01200 | 33 | 1.46 × 10−5 |
7 | Axon guidance | hsa04360 | 44 | 2.23 × 10−5 |
8 | Ras signaling pathway | hsa04014 | 52 | 3.77 × 10−5 |
9 | Glycine, serine and threonine metabolism | hsa00260 | 17 | 4.59 × 10−5 |
10 | Mineral absorption | hsa04978 | 19 | 8.74 × 10−5 |
11 | PPAR signaling pathway | hsa03320 | 23 | 1.08 × 10−4 |
12 | Wnt signaling pathway | hsa04310 | 35 | 1.53 × 10− 4 |
13 | Transcriptional misregulation in cancer | hsa05202 | 41 | 1.72 × 10−4 |
14 | AGE-RAGE signaling pathway in diabetic complications | hsa04933 | 28 | 1.74 × 10−4 |
15 | HIF-1 signaling pathway | hsa04066 | 28 | 2.28 × 10−4 |
16 | mTOR signaling pathway | hsa04150 | 36 | 3.31 × 10−4 |
17 | Fatty acid metabolism | hsa01212 | 17 | 3.32 × 10−4 |
18 | Focal adhesion | hsa04510 | 44 | 3.81 × 10−4 |
19 | Regulation of actin cytoskeleton | hsa04810 | 46 | 3.91 × 10−4 |
20 | Fatty acid degradation | hsa00071 | 16 | 3.94 × 10−4 |
21 | Steroid hormone biosynthesis | hsa00140 | 19 | 3.94 × 10−4 |
22 | Bile secretion | hsa04976 | 21 | 4.29 × 10−4 |
23 | Aldosterone-regulated sodium reabsorption | hsa04960 | 15 | 4.65 × 10−4 |
24 | Jak-STAT signaling pathway | hsa04630 | 36 | 5.50 × 10−4 |
25 | ErbB signaling pathway | hsa04012 | 24 | 6.18 × 10−4 |
26 | Steroid biosynthesis | hsa00100 | 10 | 6.33 × 10−4 |
27 | Valine, leucine and isoleucine degradation | hsa00280 | 16 | 7.02 × 10−4 |
28 | Renal cell carcinoma | hsa05211 | 20 | 7.19 × 10−4 |
29 | Biosynthesis of amino acids | hsa01230 | 21 | 9.01 × 10−4 |
30 | Tyrosine metabolism | hsa00350 | 13 | 9.74 × 10−4 |
31 | Tryptophan metabolism | hsa00380 | 14 | 1.01 × 10−3 |
32 | EGFR tyrosine kinase inhibitor resistance | hsa01521 | 22 | 1.09 × 10−3 |
33 | Cytokine-cytokine receptor interaction | hsa04060 | 51 | 1.10 × 10−3 |
34 | Arginine biosynthesis | hsa00220 | 10 | 1.11 × 10− 3 |
35 | Proximal tubule bicarbonate reclamation | hsa04964 | 10 | 1.45 × 10−3 |
36 | Sphingolipid metabolism | hsa00600 | 15 | 1.46 × 10−3 |
37 | Rap1 signaling pathway | hsa04015 | 43 | 1.48 × 10−3 |
38 | Hippo signaling pathway-multiple species | hsa04392 | 11 | 1.64 × 10−3 |
39 | FoxO signaling pathway | hsa04068 | 30 | 1.79 × 10−3 |
40 | Glycerolipid metabolism | hsa00561 | 17 | 1.84 × 10−3 |
41 | Vitamin digestion and absorption | hsa04977 | 10 | 1.87 × 10−3 |
42 | Pentose phosphate pathway | hsa00030 | 11 | 2.05 × 10−3 |
43 | cAMP signaling pathway | hsa04024 | 40 | 2.13 × 10−3 |
44 | AMPK signaling pathway | hsa04152 | 28 | 2.26 × 10−3 |
45 | Arginine and proline metabolism | hsa00330 | 15 | 2.41 × 10−3 |
46 | Alanine, aspartate and glutamate metabolism | hsa00250 | 12 | 2.60 × 10−3 |
47 | Epithelial cell signaling in Helicobacter pylori infection | hsa05120 | 18 | 3.00 × 10−3 |
48 | beta-Alanine metabolism | hsa00410 | 11 | 3.13 × 10−3 |
49 | Insulin signaling pathway | hsa04910 | 30 | 3.13 × 10−3 |
50 | Propanoate metabolism | hsa00640 | 11 | 3.81 × 10−3 |