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Table 1 Canonical pathways enriched (P < 0.001) among genes down-regulated or up-regulated in the Gns group versus the Control group

From: Effect of exogenous gonadotropin on the transcriptome of human granulosa cells and follicular fluid hormone profiles

Pathway Input number Background number Corrected P-value Genes
Pathways enriched among down-regulated genes
 Cell cycle 14 124 1.10E-07 PKMYT1, PLK1, CDC25A, TTK, CDC20, CDC25C, CCNA2, CCNB2,
 Oocyte meiosis 8 110 0.003 BUB1B, CDC45, CCNB1, CDC6, ORC6, ESPL1 PKMYT1, PLK1, CDC20, CDC25C, CCNB2, AURKA, CCNB1, ESPL1
 Steroid hormone biosynthesis 6 57 0.003 CYP19A1, HSD11B2, CYP17A1, CYP21A2
 Progesterone-mediated oocyte maturation 7 86 0.003 PKMYT1, PLK1, CDC25A, CCNB2, CDC25C, CCNA2, CCNB1
 Ovarian steroidogenesis 5 51 0.0125 FSHR, CYP19A1, CYP17A1, LHCGR
Pathways enriched among up-regulated genes
 Cytokine–cytokine receptor interaction 49 265 2.68E-10 TNFSF11, CCL28, IL1B, CCR2, CXCL3, OSM, PPBP, TNF, IL10, TNFSF8, CCL4, CXCL8, CXCR4, CD40, IL10RA, IL1R1, FLT3, CCR1, LTA, CCR5, TNFRSF11A, TGFBR2, CCL4L2, TNFRSF18, CCL22, CXCL2, CCL8, TNFSF10, CCL2, CCL20, IL6R, CSF2RA, CCL3L1, TNFSF14, TNFRSF8, TNFSF13B, IL1R2, IL6, CSF2RB, CCL3, CCR6, TNFRSF4, CRLF2, CCL7, IL18R1, IL18RAP, TNFRSF1B, IL18, CSF3R
 Chemokine signaling pathway 35 189 9.0E-08 CCL28, WAS, CCR2, CXCL3, PRKCB, PPBP, CCL4, HCK, CXCL8, CXCR4, PIK3R5, DOCK2, CCR1, CCR5, ARRB2, CCL4L2, CCL22, CXCL2, CCL8, CCL2, CCL20, CCL3L1, ADCY7, CCR6, VAV1, ADCY4, FGR, CCL3, PIK3CG
 NF-kappaB signaling pathway 23 91 1.4E-07 CCL7, NCF1, PLCB2, GNGT2,TNFSF13B, PLAU, PRKCB, TNF, BLNK, BTK, CCL4, CXCL8, CD40, LTA, BCL2A1, TNFRSF11A, CCL4L2, CXCL2, ICAM1, CD14, SYK, TNFSF14, IL1B, IL1R1, TNFSF11, LY96, GADD45B