Intercellular wireless communication network between mother and fetus in rat pregnancy-a study on directed and weighted network

Table 3 Signal molecules that showed significant changes during this period

Gestation period	Cytokines	P-value	Rate of change in concentration	Statistical analysis method
E1	LH	0.021*	0.694	Comparative t-test
E1	BDNF	0.013*	−0.425	Comparative t-test
E5	MCP-1	0.012*	23.5	Nonparametric test
	IL-10	0.016*	0.918	Comparative t-test
	IL-13	0.012*	119.0	Comparative t-test
	GRO	0.063	8.47	Comparative t-test
E7	Leptin	0.029*	1.46	Comparative t-test
	IL-1α	0.037*	14.4	Comparative t-test
	IP-10	0.041*	5.11	Comparative t-test
	IFN-γ	0.059	26.4	Comparative t-test
E9	GH	0.045*	4.05	Comparative t-test
E13	Leptin	0.093	1.12	Comparative t-test
E15	LH	0.047*	−0.590	Comparative t-test
E17	RANTES	0.002**	−0.279	Comparative t-test
	GH	0.039*	4.19	Comparative t-test
	LH	0.080	−0.519	Comparative t-test
E19	Leptin	0.005**	1.91	Comparative t-test
	TSH	0.001**	1.79	Comparative t-test
	ACTH	0.049*	−0.477	Comparative t-test
	GH	0.065	3.72	Comparative t-test
E21	ACTH	0.002**	−0.757	Comparative t-test
	BDNF	0.005**	−0.484	Comparative t-test
	IL-2	0.017*	2.77	Comparative t-test
	IL-6	0.013*	0.755	Comparative t-test
	IL-12P70	0.017*	1.11	Comparative t-test
	IL-18	0.018*	3.33	Comparative t-test
	IFN-γ	0.044*	29.9	Comparative t-test
	Leptin	0.054	1.28	Comparative t-test
	GRO	0.060	8.55	Comparative t-test
E23	ACTH	0.036*	−0.507	Comparative t-test
E23	BDNF	0.008**	−0.458	Comparative t-test
D1	VEGF	0.008**	1.61	Nonparametric test
	BDNF	0.002**	−0.531	Comparative t-test
	ACTH	0.022*	−0.559	Comparative t-test
D3	PRL	< 0.001**	4.70	Comparative t-test
	ACTH	0.023*	−0.552	Comparative t-test
	LH	0.030*	−0.648	Comparative t-test

ISSN: 1477-7827