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Table 2 Clinical/oocyte/embryo parameters from ovarian stimulation to embryo transfer relationship between serum progesterone levels and clinical pregnancy rates

From: Letrozole supplementation during controlled ovarian stimulation in expected high responders: a pilot randomized controlled study

 

Group A

Group B

Wilcoxon W/t/X2

P

Patients with P elevation on day of administraition day n(%)

15.4% (10/65)

7.7% (5/65)

1.884

0.170

RecFSH

1275 (0,2700)

1350 (787.52175)

−0.703

0.482

RecFSH/day

137.5 (0,225)

142.5 (98.44,197.73)

−1.735

0.083

Recovery rate of eggs

13 (1,28)

12 (3,34)

−1.516

0.129

Duration of GN(day)

9 (6,19)

9 (7,13)

−1.293

0.196

Fertilized egg number

8.72 ± 4.26

8.63 ± 4.15

0.132

0.895

Fertilization rate

69.2% (0,100%)

78.5% (0,100%)

−1.493

0.135

Number of cleavage

8.57 ± 4.23

8.53 ± 4.19

0.051

0.959

Cleavage rate

100% (100,100%)

100% (100,100%)

  

High-quality embryo

5 (0,13)

6 (0,14)

−0.879

0.379

Rate of production of high-quality embryos

60% (0,100%)

70% (0,100%)

−1.21

0.226

P on the day of hCG administration (ng/mL)

1.05 (0.3,2.61)

0.95 (0.15,2.06)

−2.047

0.041

E2 on the day of hCG administration (pg/mL)

1404.28 (431.36227)

2867 (1043.62,7198)

−7.131

< 0.001

P/E2 on the day of hCG administration

0.73 (0.066,1.86)

0.317 (0.043,1.84)

−6.931

< 0.001

E2 on 1 day before the day of hCG administration

546.95 (0,2611)

1102 (0,5488)

−2.055

0.040

P on 1 day before the day of hCG administration

0.545 (0,1.65)

0.52 (0,1.83)

−0.33

0.741

P on 6th day post-ET (ng/mL)

9.025 (0,96.3)

9.08 (0,44.86)

−0.407

0.984

E2 on 6th day post-ET (ng/mL)

103.4 (0,4737)

127.75 (0,2656)

−0.158

0.875

Thickness of endometrium

12.1 (9,17)

12.2 (8.3,17.8)

−0.284

0.776

Clinical pregnancy rate

53.1% (26/49)

72.9% (35/48)

4.096

0.043

Implantation rate

35.1% (33/94)

47.4% (45/95)

2.931

0.087

Incidence of OHSS

0% (0/65)

1.5% (1/65)

1.008

1.000

Live birth rate

42.9% (21/49)

62.5% (30/48)

3.752

0.053

First trimester miscarriage

7.7% (2/26)

5.7% (2/35)

0.095

1.000

Second trimester miscarriage

7.7% (2/26)

5.7% (2/35)

0.095

1.000

  1. Note: quantitative indicators subject to normal distribution were presented as mean ± standard deviation. Median (Min, Max) was not used to describe the normal distribution. Group A: letrozole 2.5 mg/day from cycle day 5 to the day before hCG administration. Group B: no letrozole; ET Embryo transfer, RecFSH Recombinant FSH, OHSS Ovarian hyperstimulation syndrome