Effects of high-fat diets on fetal growth in rodents: a systematic review

Table 2 Summary of studies identified in the updated and refined search

Species	Effect on fetal growth	Calories from fat		Total
Species	Effect on fetal growth	~ 45%	~ 60%	Total
Rat	Decrease	6	1	7
		Nivoit et al. (2009) [29]; Hayes et al. (2012) [30]; Reynolds et al. (2014) [32]; Dodson et al. (2017) [113]; Huang et al. (2017) [114]; Ye et al. (2017) [115]	Yamada-Obara et al. (2016) [116]
	No effect	0	7	7
			Srinivasan et al. (2006) [45]; Gupta et al. (2009) [47]; Mitra et al. (2009) [48]; White et al. (2009) [49]; Guberman et al. (2013) [50]; Desai et al. (2014) [51]; Lecoutre et al. (2016) [117]
	Increase	1	0	1
		Song et al. (2015) [55]
Total		7	8	15
Mouse	Decrease	0	7	7
			Niculescu and Lupu (2009) [85]; King et al. (2013) [87]; King et al. (2013)^a [88]; Sasson et al. (2015) [89]; Edlow et al. (2016) [90]; Panchenko et al. (2016) [91]; Bae-Gartz et al. (2016) [118]
	No effect	3	5	8
		Umekawa et al. (2015) [93]; Chin et al. (2017) [119]; Jonscher et al. (2017) [120]	Liang et al. (2009) [94]; Bytautiene et al. (2011) [95]; King et al. (2013)^a [88]; Murabayashi et al. (2013) [96]; Connor et al. (2018) [121]
	Increase	0	7	7
			Masuyama and Hiramatsu (2012) [99]; Masuyama and Hiramatsu (2012) [100]; Dahlhoff et al. (2014) [101]; Masuyama and Hiramatsu (2014) [102]; Masuyama et al. (2015) [103]; Masuyama et al. (2016) [122]; Nam et al. (2017) [123]
Total^a		3	18^a	21^a

^aStudy is listed in the table twice because it included two time points or multiple fat contents with different results. The total number of studies per species counts each study only once

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