Fig. 2From: Higher melatonin in the follicle fluid and MT2 expression in the granulosa cells contribute to the OHSS occurrenceHigher MT2 were found in OHSS patients and melatonin mediates AROM, VEGF and iNOS expression. Granulosa cells were collected from the OHSS patients and the non-OHSS patients. (a):MT2 mRNA expression was significantly higher in the OHSS group (p = 0.0459). (b):MT2 protein expression was significantly higher in the OHSS group. Granulosa cells of non-OHSS patients were treated with 0.005, 0.05 and 0.5 mmol/L of melatonin for 24 h. (c): melatonin of 0.5 mmol/L up-regulated AROM mRNA expression (p < 0.0063). (d): melatonin of 0.5 mmol/L up-regulated VEGF mRNA expression (p = 0.0219). (e): melatonin of 0.5 mmol/L down-regulated iNOS mRNA expression (p = 0.0037)Back to article page