Expression of the plasminogen system in the physiological mouse ovary and in the pathological polycystic ovary syndrome (PCOS) state

Table 3 PAI-1 IHC staining in various follicular sizes/stages in PCOS and control mice ovarian follicles

Follicular Size/Stage	PCOS/Controls	Number of Follicles (N)	Mean Total Area (Sum Area) (μm²)	P-value	ICC*	Percentage of Staining (Area fraction ROI) (%)	P-value	ICC*	Average Intensity of Staining (Mean Colour Intensity)	P-value	ICC*
Small (Primordial & Primary)	Controls	50	186.54 ± 338.8			14.6 ± 14.9			165.3 ± 43.4
Small (Primordial & Primary)	PCOS	60	122.7 ± 221.4	0.48	0.17	13.8 ± 18.9	0.92	0.52	155.3 ± 53.4	0.32	< 0.01
Preantral	Controls	44	1505.6 ± 1608.2			19.8 ± 16.4			178.8 ± 7.3
Preantral	PCOS	41	1836.2 ± 2356.4	0.71	0.36	19.4 ± 19.9	0.96	0.61	177.5 ± 11.8	0.82	0.73
Antral	Controls	49	9507 ± 9242			14.1 ± 11.0			175.3 ± 7.23
Antral	PCOS	53	9092 ± 13,318	0.93	0.41	14.6 ± 14.6	0.94	0.56	171.3 ± 25.8	0.41	0.05
Antral & Preovulatory	Controls	50	9326 ± 9236			13.9 ± 11.0			175.5 ± 7.41
Antral & Preovulatory	PCOS	56	10,132 ± 13,950	0.46	0	15.1 ± 14.5	0.56	0.13	171.2 ± 25.2	0.56	0.92

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