| Granulosa cells | Theca cells | Large follicles | Small follicles | General distribution |
---|
| Con | PCOS | Con | PCOS | Con | PCOS | Con | PCOS | Con | PCOS |
---|
PAI-1 | + | + | – | – | + | + | – | – | P | T |
tPA | – | – | – | – | – | – | – | – | A | A |
uPA | + | + | – | – | + | + | + | + | P | P |
Plasminogen/Plasmin | + | + | – | – | + | + | – | – | P | P |
Plasminogen only | + | + | +/− | + | + | + | – | + | T | T |
- ‘+’ = expression of marker; ‘-’ = marker absent or in low levels. PAI-1, plasminogen activator inhibitor-1; tPA, tissue plasminogen activator; uPA, urokinase plasminogen activator; Con, controls; P, peripheral; C, central; T, throughout; A, absent. The small follicles described typically represent primordial and primary follicles while the large follicles include secondary and Graafian follicles