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Table 1 Effect of low protein diet with and without supplemental folate on whole-body amino acid metabolism in rats. Methionine methyl (Qm) and carboxy (Qc) fluxes, transsulfuration (TS), transmethylation (TM), homocysteine remethylation (RM), serine flux and cysteine flux in rats

From: Preovulatory exposure to a protein-restricted diet disrupts amino acid kinetics and alters mitochondrial structure and function in the rat oocyte and is partially rescued by folic acid

Kinetics (μmol·kg− 1·h− 1)

Control (n = 8)

LP (n = 8)

LPF (n = 8)

P value

Qc

97.3 ± 4.9

126 ± 18.9

93.4 ± 13.8

0.22

Qm

112 ± 5.8

147 ± 23.7

110 ± 16.1

0.24

Methionine TM

36.0 ± 2.3 a

57.5 ± 4.5 b

56.6 ± 5.8 b

0.003

Methionine TS

21.4 ± 1.5 a

36.6 ± 3.8 b

39.9 ± 4.1 b

0.002

Homocysteine RM

14.6 ± 1.4

20.9 ± 5.0

16.6 ± 2.4

0.40

Serine flux

531 ± 43 a

751 ± 64 b

804 ± 55 b

0.005

Cysteine flux

97.7 ± 7.5

105 ± 5.8

101 ± 6.5

0.75

  1. Note: Data are mean ± SEM; LP = Low Protein; LPF = Low Protein with supplemental folate
  2. Methionine methyl (Qm) and carboxy (Qc) fluxes, transsulfuration (TS), transmethylation (TM), homocysteine remethylation (RM), serine flux and cysteine flux. Means with different superscript letters are significantly different, P < 0.05 (Tukey’s multiple comparison test)