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Table 1 Effect of low protein diet with and without supplemental folate on whole-body amino acid metabolism in rats. Methionine methyl (Qm) and carboxy (Qc) fluxes, transsulfuration (TS), transmethylation (TM), homocysteine remethylation (RM), serine flux and cysteine flux in rats

From: Preovulatory exposure to a protein-restricted diet disrupts amino acid kinetics and alters mitochondrial structure and function in the rat oocyte and is partially rescued by folic acid

Kinetics (μmol·kg− 1·h− 1) Control (n = 8) LP (n = 8) LPF (n = 8) P value
Qc 97.3 ± 4.9 126 ± 18.9 93.4 ± 13.8 0.22
Qm 112 ± 5.8 147 ± 23.7 110 ± 16.1 0.24
Methionine TM 36.0 ± 2.3 a 57.5 ± 4.5 b 56.6 ± 5.8 b 0.003
Methionine TS 21.4 ± 1.5 a 36.6 ± 3.8 b 39.9 ± 4.1 b 0.002
Homocysteine RM 14.6 ± 1.4 20.9 ± 5.0 16.6 ± 2.4 0.40
Serine flux 531 ± 43 a 751 ± 64 b 804 ± 55 b 0.005
Cysteine flux 97.7 ± 7.5 105 ± 5.8 101 ± 6.5 0.75
  1. Note: Data are mean ± SEM; LP = Low Protein; LPF = Low Protein with supplemental folate
  2. Methionine methyl (Qm) and carboxy (Qc) fluxes, transsulfuration (TS), transmethylation (TM), homocysteine remethylation (RM), serine flux and cysteine flux. Means with different superscript letters are significantly different, P < 0.05 (Tukey’s multiple comparison test)