Table 2 miRNAs, target genes and their functions in GC apoptosis and follicular atresia

let-7 g

porcine

MAP3K1

promotes GC apoptosis

[61]

let-7 g

porcine

TGFBR1

promotes GC apoptosis

[58]

miR-10b

goat

BDNF

suppresses GC proliferation

[118]

miR-15a

human

unknown

promotes release of progesterone and testosterone

[91]

miR-21

mouse

unknown

inhibits apoptosis, increases ovulation rate

[119]

miR-22

mouse

Sirt1

inhibits GC apoptosis

[120]

miR-23a

human

SMAD5

promotes GC apoptosis

[78, 121]

miR-26b

porcine

ATM

promotes GC apoptosis

[42]

miR-26b

porcine

SMAD4

promotes GC apoptosis

[64]

miR-26b

porcine

HAS2

promotes GC apoptosis

[122]

miR-27a

human

SMAD5

promotes GC apoptosis

[78]

miR-34a

porcine

INHBB

promotes GC apoptosis

[123]

miR-34c

porcine

unknown

proapoptotic and antiproliferative factor

[124]

miR-92a

porcine

SMAD7

inhibits GC apoptosis

[65]

miR-93

human

CDKN1A

promotes GC proliferation

[125]

miR-106a

human

apoptosis signal-regulating kinase 1 (ASK1)

reduces GC viability and promotes apoptosis

[111]

miR-125a-5p

mouse

Stat3

promotes GC apoptosis

[126]

miR-126*

porcine

FSHR

promotes AR-induced GC apoptosis

[127]

miR-146a

human

IRAK1/TRAF6

promotes GC apoptosis

[128]

miR-181b

porcine

SMAD7

inhibits GC apoptosis

[67]

miR-182

rat

Smad7

inhibits GC apoptosis

[66]

miR-224

mouse

Smad4

inhibits GC proliferation and E2 release

[63]

miR-320

mouse

E2f1/Sf-1

inhibits E2 synthesis and GC proliferation

[129]

miR-378-3p

bovine

PGR

inhibits GC differentiation

[130]

miR-378

porcine

CYP19A1

decreases E2 production

[88]

miR-383

mouse

Rbms1

enhances E2 release from GCs

[131]

miR-503/322/351 Cluster

mouse

Autophagy/Mitophagy-Associated Genes

reduces of mitochondrial activity in GC

[132]

miR-764-3p

mouse

Sf-1

decreases steroidogenesis

[89]

miR-1275

porcine

LRH-1

represses E2 synthesis

[50]