Skip to main content

Table 3 Results of meta-analyses and test of publication bias on embryos

From: Open versus closed vitrification system of human oocytes and embryos: a systematic review and meta-analysis of embryologic and clinical outcomes

Outcomes

Study type

No. of studies

Events/Total

RR, 95%CI, P

Test of Heterogeneity

Tests of Publication Bias

Closed

Open

Random

I2 (%)

P

Begg’s P

Egger’s P

Cryosurvival rate

Prospective

4

621/724

803/895

0.98, [0.96, 1.01], 0.29

0%

0.42

0.734

0.612

Retrospective

3

770/805

959/1013

1.00, [0.97, 1.03], 0.88

58%

0.09

1.000

0.940

Positive βHCG rate

Prospective

2

115/222

114/211

0.96, [0.80, 1.14], 0.64

0%

0.77

1.000

NA

Implantation rate

Prospective

3

160/535

196/590

0.98, [0.83, 1.15], 0.80

0%

0.93

1.000

0.798

Retrospective

4

333/839

444/1071

0.97, [0.81, 1.17], 0.76

53%

0.09

0.308

0.805

Cancellation rate

Retrospective

2

9/321

9/267

0.75, [0.18, 3.04], 0.69

30%

0.23

1.000

NA

Clinical pregnancy rate

Prospective

3

134/304

226/432

0.89, [0.76, 1.05], 0.17

0%

0.91

1.000

0.613

Retrospective

4

280/513

374/577

0.96, [0.79, 1.17], 0.69

61%

0.05

0.734

0.790

Ongoing pregnancy rate

Prospective

3

133/319

160/369

0.98, [0.82, 1.16], 0.79

0%

1.00

1.000

0.682

Retrospective

2

114/312

105/258

0.96, [0.71, 1.29], 0.77

50%

0.16

1.000

NA

Miscarriage rate

Prospective

2

4/93

8/94

0.60, [0.11, 3.31], 0.56

43%

0.18

1.000

NA

Retrospective

3

61/276

76/360

1.07 [0.79, 1.46], 0.66

0%

0.71

1.000

0.337

Live birth rate

Prospective

2

123/287

193/415

0.96, [0.81, 1.15], 0.69

0%

0.71

1.000

NA

Retrospective

4

217/513

313/577

0.88 [0.71, 1.10], 0.26

48%

0.12

0.308

0.163

Babies born/ transferred blastocysts

Retrospective

2

114/438

124/420

0.82 [0.65, 1.02], 0.09

0%

0.48

1.000

NA

Multiple birth rate

Retrospective

3

30/293

21/357

0.95 [0.41, 2.24], 0.92

52%

0.13

1.000

0.831

  1. NA not applicable, RR risk ratio