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Table 3 Results of meta-analyses and test of publication bias on embryos

From: Open versus closed vitrification system of human oocytes and embryos: a systematic review and meta-analysis of embryologic and clinical outcomes

Outcomes Study type No. of studies Events/Total RR, 95%CI, P Test of Heterogeneity Tests of Publication Bias
Closed Open Random I2 (%) P Begg’s P Egger’s P
Cryosurvival rate Prospective 4 621/724 803/895 0.98, [0.96, 1.01], 0.29 0% 0.42 0.734 0.612
Retrospective 3 770/805 959/1013 1.00, [0.97, 1.03], 0.88 58% 0.09 1.000 0.940
Positive βHCG rate Prospective 2 115/222 114/211 0.96, [0.80, 1.14], 0.64 0% 0.77 1.000 NA
Implantation rate Prospective 3 160/535 196/590 0.98, [0.83, 1.15], 0.80 0% 0.93 1.000 0.798
Retrospective 4 333/839 444/1071 0.97, [0.81, 1.17], 0.76 53% 0.09 0.308 0.805
Cancellation rate Retrospective 2 9/321 9/267 0.75, [0.18, 3.04], 0.69 30% 0.23 1.000 NA
Clinical pregnancy rate Prospective 3 134/304 226/432 0.89, [0.76, 1.05], 0.17 0% 0.91 1.000 0.613
Retrospective 4 280/513 374/577 0.96, [0.79, 1.17], 0.69 61% 0.05 0.734 0.790
Ongoing pregnancy rate Prospective 3 133/319 160/369 0.98, [0.82, 1.16], 0.79 0% 1.00 1.000 0.682
Retrospective 2 114/312 105/258 0.96, [0.71, 1.29], 0.77 50% 0.16 1.000 NA
Miscarriage rate Prospective 2 4/93 8/94 0.60, [0.11, 3.31], 0.56 43% 0.18 1.000 NA
Retrospective 3 61/276 76/360 1.07 [0.79, 1.46], 0.66 0% 0.71 1.000 0.337
Live birth rate Prospective 2 123/287 193/415 0.96, [0.81, 1.15], 0.69 0% 0.71 1.000 NA
Retrospective 4 217/513 313/577 0.88 [0.71, 1.10], 0.26 48% 0.12 0.308 0.163
Babies born/ transferred blastocysts Retrospective 2 114/438 124/420 0.82 [0.65, 1.02], 0.09 0% 0.48 1.000 NA
Multiple birth rate Retrospective 3 30/293 21/357 0.95 [0.41, 2.24], 0.92 52% 0.13 1.000 0.831
  1. NA not applicable, RR risk ratio