Skip to main content

Table 2 Results of meta-analyses and test of publication bias on oocytes

From: Open versus closed vitrification system of human oocytes and embryos: a systematic review and meta-analysis of embryologic and clinical outcomes

Outcomes Study type No. of studies Events/Total RR, 95%CI, P Test of Heterogeneity Tests of Publication Bias
Closed Open Random I2 (%) P Begg’s P Egger’s P
Cryosurvival rate Prospective 4 830/986 967/1062 0.91, [0.80, 1.03], 0.14 91% 0.00 1.000 0.921
Retrospective 1 222/268 151/261 1.43, [1.27, 1.61], < 0.01 NA NA NA NA
Fertilization rate Prospective 2 585/733 594/784 1.02, [0.83, 1.24], 0.88 92% 0.00 1.000 NA
Retrospective 1 116/159 87/151 1.27, [1.07, 1.50], < 0.01 NA NA NA NA
Good quality embryo rate Prospective 2 229/561 240/566 0.97, [0.84, 1.11], 0.62 0% 0.96 1.000 NA
Retrospective 1 62/112 30/87 1.61, [1.15, 2.24], < 0.01 NA NA NA NA
Positive βHCG rate Prospective 2 45/109 47/125 1.09, [0.75, 1.59], 0.64 22% 0.26 1.000 NA
Miscarriage rate Prospective 2 4/38 8/39 0.59, [0.20, 1.79], 0.35 0% 0.84 1.000 NA
Ongoing pregnancy rate Prospective 2 38/125 27/109 1.24, [0.81, 1.89], 0.32 0% 0.45 1.000 NA
Clinical pregnancy rate Prospective 1 27/75 21/75 1.29, [0.80, 2.06], 0.30 NA NA NA NA
Retrospective 1 14/53 4/51 3.37, [1.19, 9.55], 0.02 NA NA NA NA
Live birth rate Prospective 1 27/75 18/75 1.50, [0.91, 2.48], 0.11 NA NA NA NA
Retrospective 1 11/53 3/51 3.53, [1.04, 11.92], 0.04 NA NA NA NA
  1. NA not applicable, RR risk ratio