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Table 1 The characteristics of included studies

From: Effects of ADIPOQ polymorphisms on PCOS risk: a meta-analysis

First author, year Country Ethnicity Age (years)
Case/Control
Sample size Genotype distribution P-value for HWE NOS score
Cases Controls
rs1501299 G/T      GG/GT/TT GG/GT/TT   
 Alfaqih 2018 [16] Jordon West Asian 23.9/24.2 154/151 62/77/15 64/54/33 0.002 8
 Czeczuga-Semeniuk 2018 [17] Poland Caucasian 24.6/23.2 294/78 156/117/21 25/49/4 0.002 8
 Escobar-Morreale 2006 [19] Spain Caucasian NA 76/40 30/39/7 15/21/4 0.390 7
 Heinonen 2005 [21] Finland Caucasian NA 143/245 77/58/8 110/110/25 0.744 7
 Li 2011 [22] Korea East Asian NA 144/159 61/73/10 48/87/24 0.131 7
 Nambiar 2016 [23] India West Asian 28.6/31.1 282/200 94/165/23 86/99/15 0.060 8
 Pau 2013 [25] USA Mixed NA 525/472 NA NA NA 7
 Radavelli-Bagatini 2013 [26] Brazil Mixed NA 80/1500 42/27/11 671/672/157 0.556 7
 Ramezani Tehrani 2013 [27] Iran West Asian 26.6/30.8 186/156 92/76/18 77/71/8 0.100 7
 Ranjzad 2012 [28] Iran West Asian 27.1/31.1 181/181 92/77/12 91/79/11 0.254 8
 San Millán 2004 [29] Spain Caucasian 24.6/31.1 72/42 28/34/10 18/20/4 0.643 7
 Xita 2005 [30] Greece Caucasian 23.7/24.8 100/140 39/49/12 52/73/15 0.152 7
 Yoshihara 2009 [31] Japan East Asian 29.1/29.8 38/97 19/15/4 58/24/15 < 0.001 8
 Zhang 2008 [32] China East Asian 28.7/29.6 120/120 56/46/18 41/50/29 0.083 8
 Zhang 2015 [33] China East Asian 27.0/27.2 207/192 119/78/10 95/75/22 0.229 7
rs2241766 T/G      TT/TG/GG TT/TG/GG   
 Alfaqih 2018 [16] Jordon West Asian 23.9/24.2 154/149 92/48/14 93/42/14 0.008 8
 Czeczuga-Semeniuk 2018 [17] Poland Caucasian 24.6/23.2 294/78 255/39/0 62/16/0 0.313 8
 Demirci 2010 [18] Turkey Caucasian 24.1/23.8 96/93 70/20/6 74/16/3 0.091 8
 Escobar-Morreale 2006 [19] Spain Caucasian NA 76/40 55/20/1 26/13/1 0.673 7
 Haap 2005 [20] Germany Caucasian 27.4/38.9 53/542 38/8/7 414/112/16 0.016 8
 Heinonen 2005 [21] Finland Caucasian NA 143/245 125/17/1 222/22/1 0.572 7
 Li 2011 [22] Korea East Asian NA 144/159 79/59/6 72/84/3 < 0.001 7
 Nambiar 2016 [23] India West Asian 28.6/31.1 282/200 213/60/9 156/40/4 0.453 8
 Panidis 2004 [24] Greece Caucasian 23.4/29.4 132/100 92/33/7 81/17/2 0.340 7
 Radavelli-Bagatini 2013 [26] Brazil Mixed NA 80/1500 64/14/2 1122/356/22 0.297 7
 Ramezani Tehrani 2013 [27] Iran West Asian 26.6/30.8 186/156 142/42/2 106/46/4 0.707 7
 Ranjzad 2012 [28] Iran West Asian 27.1/31.1 181/181 144/34/2 121/54/6 0.993 8
 San Millán 2004 [29] Spain Caucasian 24.6/31.1 72/42 48/22/2 29/12/1 0.853 7
 Xita 2005 [30] Greece Caucasian 23.7/24.8 100/140 77/23/0 106/30/4 0.306 7
 Yoshihara 2009 [31] Japan East Asian 29.1/29.8 38/97 19/19/0 53/29/15 0.004 8
 Zhang 2008 [32] China East Asian 28.7/29.6 120/120 57/54/9 74/42/4 0.504 8
 Zhang 2015 [33] China East Asian 27.0/27.2 207/192 106/84/17 98/75/19 0.409 7
  1. PCOS Polycystic ovary syndrome, HWE Hardy-Weinberg equilibrium, NOS Newcastle-Ottawa scale, NA Not available