Skip to main content
Fig. 4 | Reproductive Biology and Endocrinology

Fig. 4

From: Protective effects of mangafodipir against chemotherapy-induced ovarian damage in mice

Fig. 4

Mangafodipir rescues follicles from anticancer drug-induced oxidative stress. a Representative images of immunohistochemistry for 4-HNE in ovaries treated with 7.5 (CIS7.5) or 20 (CIS20) mg/kg cisplatin, or 7.5 (PTX7.5) or 20 (PTX20) mg/kg paclitaxel, with or without mangafodipir (+/− Mangafodipir, respectively). Bar, 100 μm. b 4-HNE immunoreactive intensity scores. Mean ± SD, *, p < 0.05. c Mangafodipir (m.10 mg/kg) reduced 4-HNE induced by 7.5 (CIS7.5), 20 (CIS20) mg/kg cisplatin, 7.5 (PTX7.5) or 20 (PTX20) mg/kg paclitaxel. The relative intensities of 4-HNE signals were normalized to those of β-actin to assess the results of the immunoblot in mice ovaries. Mean ± SEM, *, p < 0.05 vs. each control (m0)

Back to article page